Results 111 to 120 of about 9,629,189 (256)
Isolation, marine transgression and translocation of the bare‐nosed wombat (Vombatus ursinus)
Evolutionary Applications, 2019 Island populations can represent genetically distinct and evolutionarily important lineages relative to mainland conspecifics. However, phenotypic divergence of island populations does not necessarily reflect genetic divergence, particularly for lineages
Alynn Martin +6 more
doaj +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Urban spatial structure and suburbanisation. The case of the Barcelona Metropolitan [PDF]
The metropolitan spatial structure displays various patterns, sometimes monocentricity and sometimes multicentricity, which seems much more complicated than the exponential density function used in classic works such as Clark (1961), Muth (1969) or Mills
Ana Galindo +2 more
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Spatial variability of groundwater recharge - II. Factors affecting variability and taking account of it in estimating recharge [PDF]
, 2004 The accompanying paper provided evidence to suggest that spatial variability of groundwater recharge is ‘true’ variability. This paper attempts to determine the major causes of such variability even at small distances, if there appear to be a frequency ...
De Silva, RP
core
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Workbook for Quantitative Methods and Socio-Economic Applications in GIS
This webinar will introduce the project on "the Workbook for Quantitative Methods and Socioconomic Application in GIS", and how to join the spatial data lab on those ongoing spacial social science research and development ...
Spatial, Data Lab
core +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Shaking table test a hybrid spatial structure with engineering application [PDF]
, 2009 p. 420-431Terminal building 2 in Shanghai pudong international airport is a novel hybrid spatial structure. The upper steel roof and lower reinforced concrete frame are assembled with Yshaped steel columns.
LIU, Feng, LU, Xilin
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