Results 61 to 70 of about 9,629,189 (256)
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Spatial variability of soil nitrogen forms and the activity of N-cycle enzymes
Plant, Soil and Environment, 2016 Knowledge about the spatio-temporal variability of soil chemical and biological properties is crucial in evaluating their structure-function relationship and their impact on ecosystem functions.
J. Długosz, A. Piotrowska-Długosz
doaj +1 more source
Analysis The Pattern of Physical and Spatial Development by Holdern Model Case Staudy: Gonabad City [PDF]
جغرافیا و آمایش شهری منطقهای, 2016 The cities, during their life will change and develop due to different factors, but a good city is a city which its physic provides the requirements of its residents with respect to the time changes. Uncontrolled expansion and development of urban areas
dr. bakhtiyar ezat panah +1 more
doaj +1 more source
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
Spatial Interactions and resilience in arid ecosystems [PDF]
, 2004 We present a mathematical analysis of the consequences of spatial interactions between vegetation patches by means of water flow for the functioning of arid systems.
Van de Koppel, J. +5 more
core +3 more sources
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
The Effect of Railway Travel on Urban Spatial Structure [PDF]
, 2014 We examine the effect of railway travel on urban spatial structure in a polycentric urban land use model. We focus on the role of access to the railway network. We find that if the number of train stations is limited, the degree of urbanization is higher
Dröes, Martijn I. +3 more
core
On the Choice of Genetic Distance in Spatial-Genetic Studies. [PDF]
, 2007 We look at how to choose genetic distance so as to maximise the power of detecting spatial structure. We answer this question through analysin g two population genetic models that allow for a spatially structured population in a continuous habitat. These
Fearnhead, P
core +4 more sources
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source