Results 1 to 10 of about 68,356 (275)

HiSTaR: identifying spatial domains with hierarchical spatial transcriptomics variational autoencoder [PDF]

Journal of Translational Medicine
Background The development of spatial transcriptomics (ST) has enabled biologists to measure transcriptome data on an entire tissue and retain spatial information.
Junhua Yu, Jiaqi Yuan, Qianbei Yi, Zheng Ye, Peng Xu, Wenbin Liu   +5 more
doaj   +2 more sources

Multiscale Cell–Cell Interactive Spatial Transcriptomics Analysis [PDF]

Advanced Science
Spatial transcriptomics data analysis integrates gene expression profiles with their corresponding spatial locations to identify spatial domains, infer cell‐type dynamics, and detect gene expression patterns within tissues.
Sean Cottrell, Guo‐Wei Wei
doaj   +2 more sources

Modeling zero inflation is not necessary for spatial transcriptomics

Genome Biology, 2022
Background Spatial transcriptomics are a set of new technologies that profile gene expression on tissues with spatial localization information. With technological advances, recent spatial transcriptomics data are often in the form of sparse counts with ...
Peiyao Zhao, Jiaqiang Zhu, Ying Ma, Xiang Zhou   +3 more
doaj   +1 more source

Review of precision cancer medicine: Evolution of the treatment paradigm. [PDF]

, 2020
In recent years, biotechnological breakthroughs have led to identification of complex and unique biologic features associated with carcinogenesis. Tumor and cell-free DNA profiling, immune markers, and proteomic and RNA analyses are used to identify ...
Fountzilas, Elena, Kurzrock, Razelle, Nikanjam, Mina, Tsimberidou, Apostolia M   +3 more
core   +1 more source

Single-cell spatial explorer: easy exploration of spatial and multimodal transcriptomics

BMC Bioinformatics, 2023
Background: The development of single-cell technologies yields large datasets of information as diverse and multimodal as transcriptomes, immunophenotypes, and spatial position from tissue sections in the so-called ’spatial transcriptomics’.
Frédéric Pont, Juan Pablo Cerapio, Pauline Gravelle, Laetitia Ligat, Carine Valle, Emeline Sarot, Marion Perrier, Frédéric Lopez, Camille Laurent, Jean Jacques Fournié, Marie Tosolini   +10 more
doaj   +1 more source

Arguments for and against self and non-self root recognition in plants [PDF]

, 2014
Root–root interaction research gained more and more attention over the past few years. Roots are pivotal for plant survival because they ensure uptake of water and nutrients.
Depuydt, Stephen
core   +5 more sources

Opportunities and challenges in the application of single-cell and spatial transcriptomics in plants

Frontiers in Plant Science, 2023
Single-cell and spatial transcriptomics have diverted researchers’ attention from the multicellular level to the single-cell level and spatial information.
Ce Chen, Yining Ge, Lingli Lu, Lingli Lu
doaj   +1 more source

Computational Cancer Biology: An Evolutionary Perspective [PDF]

, 2016
ISSN:1553-734XISSN:1553 ...
A Deutsch, A Fischer, A Gonzalez-Perez, A Roth, A Schuh, A Tofigh, A Trinh, AM Newman, BJ Raphael, C Guichard, C Tomasetti, C Tomasetti, CD Greenman, Chris D. Greenman, CO Nordling, CS Cooper, CS-O Attolini, E Purdom, E Szczurek, ER Fearon, F Michor, F Ronquist, F Strino, F Vandin, H Shahrabi Farahani, H Zare, I Bozic, I Bozic, I Martincorena, J Diaz, J Foo, J Rahnenführer, J Shendure, Jens Lagergren, JH Goldie, K Yuan, KI Kim, L Oesper, LJ Barber, LMF Merlo, LR Yates, M Consequences, M Gerlinger, M Gerstung, M Gerstung, M Gerstung, M Hjelm, M Kimmel, MDM Leiserson, MDM Leiserson, MDM Leiserson, MF Berger, MS Lawrence, N Beerenwinkel, N Beerenwinkel, N Beerenwinkel, N Crosetto, N Navin, NE Navin, Niko Beerenwinkel, P Armitage, P Eirew, P Haccou, PC Nowell, PS Larson, R Desper, R Durrett, RF Schwarz, Ruth Nussinov, S Constantinescu, S Nik-Zainal, S Nik-Zainal, S Turajlic, S Turajlic, SA Chowdhury, SA Chowdhury, SE Luria, T Sakoparnig, V Almendro, W Jiao, WJ Ewens, Y Iwasa   +81 more
core   +2 more sources

The physiology of movement [PDF]

, 2020
Movement, from foraging to migration, is known to be under the influence of the environment. The translation of environmental cues to individual movement decision making is determined by an individual's internal state and anticipated to balance costs and
Bonte, Dries, Goossens, Steven, Van Leeuwen, Thomas, Wybouw, Nicky   +3 more
core   +2 more sources

Physico-chemical foundations underpinning microarray and next-generation sequencing experiments [PDF]

, 2013
Hybridization of nucleic acids on solid surfaces is a key process involved in high-throughput technologies such as microarrays and, in some cases, next-generation sequencing (NGS).
A. Buhot, A. E. Pozhitkov, A. Halperin, A. Harrison, A. Ott, Amend, B. M. Pettitt, Berger, Binder, Binder, Binder, Binder, Bolstad, Bullard, Burden, Burden, C. Gibas, C. J. Burden, Chou, Chou, Czypionka, D. P. Kreil, D. Tautz, E. Carlon, Fasold, Fasold, Fiche, Fuchs, H. Binder, Halperin, Harr, Harrison, He, Heim, Held, Hooyberghs, Huettel, Iltumur, Irizarry, Irizarry, Irizarry, Irving, J. Hooyberghs, Kane, L. J. Gamble, Lee, Lee, Letowski, Li, Liebich, Lockhart, Luebke, Marshall, Matveeva, Mueckstein, Mulders, Naiser, Naiser, P. A. Noble, Pingel, Pozhitkov, R. Levicky, Relogio, Rouillard, Tanaka, Trapp, Upton, Vainrub, Wodicka, Yu, Zhang   +70 more
core   +3 more sources