Results 91 to 100 of about 1,207,920 (306)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Urban growth and territorial dynamics in Spain (1985-2001): A spatial econometrics analysis [PDF]

The study of the territorial/regional development in Spain has nowadays a relatively long tradition, but from the point of view of cities development the number of studies and documents decreases drastically.
Coro Chasco Yrigoyen, José María Mella Márquez   +1 more
core  

Cis‐regulatory and long noncoding RNA alterations in breast cancer – current insights, biomarker utility, and the critical need for functional validation

Molecular Oncology, EarlyView.
The noncoding region of the genome plays a key role in regulating gene expression, and mutations within these regions are capable of altering it. Researchers have identified multiple functional noncoding mutations associated with increased cancer risk in the genome of breast cancer patients.
Arnau Cuy Saqués, Aracele Martinez‐Mendez, John Crown, Alex Eustace   +3 more
wiley   +1 more source

Configuration and design in caring environments: syntax and quality of life in a sample of residential care homes for older people [PDF]

, 2005
Space syntax techniques for the analysis of spatial layouts were the first to demonstrate, in a numerical way, clear and systematic relations between spatial design and observedfunctioning across a range of building and urban types.
Hanson, J, Zako, R
core  

Perceptual Scale Expansion: An Efficient Angular Coding Strategy For Locomotor Space [PDF]

, 2011
Whereas most sensory information is coded on a logarithmic scale, linear expansion of a limited range may provide a more efficient coding for the angular variables important to precise motor control.
Durgin, Frank H., Li, Z.
core   +2 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Improving surveillance of emerging infectious diseases: ecological modelling of the spatial distribution of wild waterbirds to identify main areas of avian influenza viruses circulation in the Inner Niger Delta, Mali [PDF]

, 2010
Predicting areas of emergence when no epidemiological data is yet available is essential to implement efficient surveillance programs. The Inner Niger Delta (IND) in Mali is a major African wetlands where >1 million Palearctic and African waterbirds ...
Cappelle, Julien, Fofana, Bouba, Gaidet, Nicolas, Gilbert, M., Girard, Olivier   +4 more
core  

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

The AIDS epidemic in the Amazon region: a spatial case-control study in Rondonia, Brazil

Revista de Saúde Pública, 2013
OBJECTIVE To analyze spatial changes in the risk of AIDS and the relationship between AIDS incidence and socioeconomic variables in the state of Rondonia, Amazon region.
Maria Rita Donalisio, Ricardo Cordeiro, Roberto Wagner Lourenco, J Christopher Brown   +3 more
doaj   +1 more source