Results 51 to 60 of about 399,398 (280)

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

STAS: Spatiotemporal analysis space

, 2022
Due to the ever increasing availability of geo-data and the complexity of analytical problems, the need to enable collaborative work among analysts from diverse backgrounds (e.g., domain experts, data analysts, scientist, and laypersons) is becoming more pressing and prominent.
openaire   +2 more sources

Function‐driven design of a surrogate interleukin‐2 receptor ligand

FEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang, Zelin Cheng, Teng Li, Fulian Wang, Liangminghui Zhang, Xiuxiu He, Lili Liu, Wei Wang, Aibin Liang, Guang Yang   +9 more
wiley   +1 more source

Detecting the Seasonal and Spatial Patterns of COVID-19 Hospitalization and Deaths in Iran: Insights from a Spatiotemporal and Hotspot Analysis

International Journal of Preventive Medicine
Background: Understanding the seasonal and spatial patterns of COVID-19 hospitalization and deaths is crucial for effective hospital management, resource allocation, and public health interventions.
Leila Mounesan, Ebrahim Farhadi, Sana Eybpoosh, Ali Hosseini, Mahboubeh Parsaeian, Safoora Gharibzadeh, Mozhgan Ahmadinezhad, Farideh Bahari, Mohammad Mehdi Gouya, Aliakbar Haghdoost, Ehsan Mostafavi   +10 more
doaj   +1 more source

Phase reduction approach to synchronization of spatiotemporal rhythms in reaction-diffusion systems

, 2014
Reaction-diffusion systems can describe a wide class of rhythmic spatiotemporal patterns observed in chemical and biological systems, such as circulating pulses on a ring, oscillating spots, target waves, and rotating spirals. These rhythmic dynamics can
Kawamura, Yoji, Nakao, Hiroya, Yanagita, Tatsuo   +2 more
core   +2 more sources

Controlling spatiotemporal chaos in oscillatory reaction-diffusion systems by time-delay autosynchronization [PDF]

, 2004
Diffusion-induced turbulence in spatially extended oscillatory media near a supercritical Hopf bifurcation can be controlled by applying global time-delay autosynchronization. We consider the complex Ginzburg-Landau equation in the Benjamin-Feir unstable
A.S. Mikhailov, Aranson, Baba, Battogtokh, Battogtokh, Beck, Ben-Jacob, Bertram, Bertram, Beta, Bär, C. Beta, Carroll, Coullet, Cross, Ditto, Franceschini, Harrington, Imbihl, Jakubith, Just, Kim, Krischer, Kuramoto, Mikhailov, Ott, Parmananda, Petrov, Pierre, Pyragas, Schuster, Schöll, Socolar, Winfree, Yeung, Zaikin   +35 more
core   +2 more sources

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Analysis of Absorbing Aerosols for Ground-Based Astronomical Observatories in Türkiye

Journal of Anatolian Physics and Astronomy
In this study, the impact of aerosols on ground-based astronomical observations in Türkiye was examined, and their spatial and temporal variations were assessed. Satellite data was used in the study due to its advantage of wide area coverage.
Fethullah Polat, Kazım Kaba, Sima Aydın   +2 more
doaj   +1 more source

Spatiotemporal Hydrological Analysis

International Journal of Hydrology, 2017
Hydrological studies need an essential forward movement in the area of spatiotemporal modelling and data analysis During the last years there has been a significant increase in global spatial data available from different sources This considerable amount of data is creating the need for a change in how to approach the spatiotemporal analyses of ...
openaire   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source