Results 31 to 40 of about 5,537,609 (250)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

open access: yesFEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa   +2 more
wiley   +1 more source

The Spatiotemporal Impact of Socio-Economic Factors on Carbon Sink Value: A Geographically and Temporally Weighted Regression Analysis at the County Level from 2000 to 2020 in China’s Fujian Province

open access: yesLand
Evaluating the economic value of carbon sinks is fundamental to advancing carbon market mechanisms and supporting sustainable regional development. This study focuses on Fujian Province in China, aiming to assess the spatiotemporal evolution of carbon ...
Tao Wang, Qi Liang
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

Spatiotemporal Characteristics and Associated Circulation Features of Summer Extreme Precipitation in the Yellow River Basin

open access: yesAtmosphere
By utilizing daily precipitation data from 400 meteorological stations in the Yellow River Basin (YRB) of China, atmospheric and oceanic reanalysis data, this study investigates the climatological characteristics, leading modes, and relationships with ...
Degui Yao, Xiaohui Wang, Jinyu Wang
doaj   +1 more source

Spatial biology in cancer epigenetics

open access: yesMolecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Construction of a Compound Heat and Drought Damage Index and Spatiotemporal Characteristics for Tea Plants in South of the Yangtze River and South China

open access: yes应用气象学报
Based on daily maximum temperature and precipitation data of tea regions over South of the Yangtze River and South China from 494 meteorological stations from 1961 to 2022, as well as records of compound heat and drought damage of tea trees, a compound ...
Li Xin   +6 more
doaj   +1 more source

The Spatiotemporal Dynamics and Socioeconomic Factors of SO2 Emissions in China: A Dynamic Spatial Econometric Design

open access: yesAtmosphere, 2019
With the great strides of China’s economic development, air pollution has become the norm that is a cause of broad adverse influence in society.
Zhimin Zhou
doaj   +1 more source

Spatiotemporal systems: gradual variations, identification, adaptation and robustness [PDF]

open access: yes, 2009
Motivated by the increasing size of complex systems by mere interconnection of simple units, this dissertation considers a set of important open research problems related to the stability, identi fication, adaptation and robustness of spatiotemporal ...
Sarwar, Azeem
core  

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

open access: yesFEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz   +6 more
wiley   +1 more source

Understanding Public Emotions: Spatiotemporal Dynamics in the Post-Pandemic Era Through Weibo Data

open access: yesBehavioral Sciences
Prolonged exposure to public health crises in the post-pandemic era poses significant threats to global mental health. To address this, we developed a conceptual model to analyse the spatiotemporal distribution of public emotions, using Weibo data from ...
Yi Liu   +3 more
doaj   +1 more source

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