Results 221 to 230 of about 3,392,268 (301)

Chiral Nanoparticles Suppress Inflammatory Infiltration to Promote Extracellular Matrix Remodeling for Ectopia Lentis Therapy

Advanced Science, EarlyView.
L‐cysteine‐configured chiral polyurethane nanoparticles suppress ocular inflammation and reduce extracellular matrix (ECM) degradation in ectopia lentis by regulating macrophages polarization and inhibiting nuclear factor kappa B signaling pathway. By promoting zonular fiber‐associated protein restoration and tissue repair, this minimally invasive ...
Yinuo Wen, Yan Yang, Haihan Gao, Yan Liu, Xinyue Wang, Linghao Song, Ruohong Li, Ao Miao, Jie Xu, Zhennan Zhao, Dan Li, Shenjie Peng, Linzhao Li, Min Zhang, Yonghang Liu, Liren Wang, Tianhui Chen, Yongxiang Jiang   +17 more
wiley   +1 more source

Spatiotemporal dynamics of the host-tumor metabolic interface: Implications for precision nutritional oncology. [PDF]

Genes Dis
Li M, Huang C, Yu S.
europepmc   +1 more source

Transforming Brain Organoids Into Functional Platforms: Convergence of Engineering, Imaging, AI, and Ethics

Advanced Science, EarlyView.
Brain organoids are emerging as increasingly functional human‐relevant platforms, yet limitations in vascularization, maturation, measurement, and reproducibility still constrain their translational value. This Perspective examines how microfluidics, biofabrication, advanced imaging, electrophysiology, multimodal AI, standardization, and ethical ...
Aishwarya Pantula, Kaustubh Joshi, Swarangi Samant, Greta Babakhanova, Annie Kathuria   +4 more
wiley   +1 more source

Spatiotemporal dynamics of tau extent and load increase in Alzheimer's disease across four longitudinal cohorts. [PDF]

Nat Aging
Macedo AC, Trudel L, Therriault J, Rahmouni N, Aumont É, Bezgin G, Hosseini SA, Tissot C, Chan T, Servaes S, Hall B, Wang YT, Quispialaya-Socualaya K, Woo MS, Fernandez-Arias J, Stevenson J, Zheng Y, Gonçalves MP, Lussier FZ, Ferrari-Souza JP, Ferreira PCL, Bellaver B, Povala G, Amaral LSD, Massarweh G, Soucy JP, Meeker KL, Braskie MN, Betthauser TJ, Christian BT, Rea Reyes RE, Caldwell JK, Ashton NJ, Karikari TK, Zetterberg H, Blennow K, Zimmer ER, Benedet AL, Johnson SC, Pascoal TA, Rosa-Neto P, Alzheimer’s Disease Neuroimaging Initiative.   +41 more
europepmc   +1 more source

Selenium Nanoparticles Selectively Target KRAS G13D to Inhibit Colorectal Cancer

Advanced Science, EarlyView.
The mechanisms of SeNPs therapy in cancer treatment, encompass three parallel actions: (1) seleno‐amino acids, key metabolites, upregulate GPX2 expression, thereby inhibiting tumor metastasis via the GPX2‐HIF1α‐VEGF signaling pathway; (2) selenite (SeO32−), an inorganic metabolite, forms hydrogen bonds with amino acid residues 13–17 of the KRAS G13D ...
Xiaoting Liu, Chong Wu, Shiyao Song, Li Ma, Shaoqing Huang, Yuting He, Qinghai Li, Yanzhou Chang, Dan Jiang, Yong Mei, Junchao Cai, Zhenshuang Du, Tianfeng Chen, Weiling He   +13 more
wiley   +1 more source

Spatiotemporal dynamics of population change in flood risk zones of the Pearl River Delta (1985-2024). [PDF]

Sci Rep
Wang J, Wu J.
europepmc   +1 more source

Performance–Complexity Trade‐Offs in Battery Lifetime Prediction with Task‐Aware Transformers

Advanced Science, EarlyView.
FAST‐BatPro integrates convolutional feature extraction, flash Attention, and sparse attention for efficient battery lifetime prediction. Using limited early‐cycle data across multiple chemistries and operating conditions, it achieves robust accuracy while reducing inference latency, computational cost, and energy consumption.
Jingyuan Zhao, Misheng Cai, Zhenghong Wang, Yan Wang, Yuqi Li, Bo Dong, Hewu Wang, Andrew F. Burke, Simona Onori, Stephen J. Harris   +9 more
wiley   +1 more source

Spatiotemporal dynamics of bile acid profiles in broilers from hatch to market age. [PDF]

Poult Sci
Luo S, Tan R, Duan Q, He W, Liu Y, Chen Y.   +5 more
europepmc   +1 more source

A Molecular Engineering Strategy to Fine‐Tune Phototoxicity of AIE Probes for Super‐Resolution Imaging of Mitochondrial Cristae Dynamics

Advanced Science, EarlyView.
Regulation of molecular packing, phototoxicity, and ROS output of AIE photosensitizers is achieved through carboxylation and alkyl‐chain‐length tuning. The probe designed via this strategy enables super‐resolution visualization of inner‐mitochondrial‐membrane cristae dynamics under controlled oxidative stress, and fluorescence‐lifetime imaging of ...
Kongqi Chen, Mengjie Wang, Chuen Kam, Zhiming Wang, Qinrong Zhang, Sijie Chen   +5 more
wiley   +1 more source

Spatiotemporal dynamics of brain pericytes in ischemic stroke. [PDF]

J Neuroinflammation
Zhong X, Ye Z, Liu L, Hui Z, Wang S, Zhang A, Zhu G, Zhao F, Li M, Zhang Z, Hu Y.   +10 more
europepmc   +1 more source