Results 41 to 50 of about 3,392,268 (301)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

A spatiotemporal characterization method for the dynamic cytoskeleton

Cytoskeleton, 2016
The significant gap between quantitative and qualitative understanding of cytoskeletal function is a pressing problem; microscopy and labeling techniques have improved qualitative investigations of localized cytoskeleton behavior, whereas quantitative analyses of whole cell cytoskeleton networks remain challenging.
Alhussein, Ghada, Shanti, Aya, Farhat, Ilyas A. H., Timraz, Sara B. H., Alwahab, Noaf S. A., Pearson, Yanthe E., Martin, Matthew N., Christoforou, Nicolas, Teo, Jeremy C. M.   +8 more
openaire   +4 more sources

Spatiotemporal dynamics of the COPI vesicle machinery [PDF]

The EMBO Reports, 2003
Assembly of the coat protein I (COPI) vesicle coat is controlled by the small GTPase ADP ribosylation factor 1 (ARF1) and its GTPase-activating protein, ARFGAP1. Here, we investigate the diffusional behaviours of coatomer, the main component of the coat, and also those of ARF1 and ARFGAP1. Using fluorescence-correlation spectroscopy, we found that most
Markus, Elsner, Hitoshi, Hashimoto, Jeremy C, Simpson, Dan, Cassel, Tommy, Nilsson, Matthias, Weiss   +5 more
openaire   +2 more sources

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

Spatiotemporal dynamics of a diffusive nutrient-phytoplankton model with delayed nutrient recycling

Nonlinear Analysis
In this paper, we investigate the spatiotemporal dynamics of a diffusive nutrient-phytoplankton model with delayed nutrient recycling. We first study the stability of positive equilibrium and Turing instability induced by diffusion.
Yun Yang, Yanfei Du
doaj   +1 more source

Orographic Factors as a Predictor of the Spread of the Siberian Silk Moth Outbreak in the Mountainous Southern Taiga Forests of Siberia

Land, 2021
This research is dedicated to solving an urgent problem associated with the large-scale destruction of taiga forests by Siberian silk moth (Dendrolimus sibiricus) outbreaks.
Svetlana M. Sultson, Andrey A. Goroshko, Sergey V. Verkhovets, Pavel V. Mikhaylov, Valery A. Ivanov, Denis A. Demidko, Sergey S. Kulakov   +6 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Dual Color Sensors for Simultaneous Analysis of Calcium Signal Dynamics in the Nuclear and Cytoplasmic Compartments of Plant Cells

Frontiers in Plant Science, 2018
Spatiotemporal changes in cellular calcium (Ca2+) concentrations are essential for signal transduction in a wide range of plant cellular processes. In legumes, nuclear and perinuclear-localized Ca2+ oscillations have emerged as key signatures preceding ...
Audrey Kelner, Nuno Leitão, Mireille Chabaud, Myriam Charpentier, Fernanda de Carvalho-Niebel   +4 more
doaj   +1 more source

A CPG‐Based Versatile Control Framework for Metameric Earthworm‐Like Robotic Locomotion

Advanced Science, 2023
Annelids such as earthworms are considered to have central pattern generators (CPGs) that generate rhythms in neural circuits to coordinate the deformation of body segments for effective locomotion. At present, the states of earthworm‐like robot segments
Qinyan Zhou, Jian Xu, Hongbin Fang
doaj   +1 more source

Air Quality Improvement in China: Evidence from PM_2.5 Concentrations in Five Urban Agglomerations, 2000–2021

Atmosphere, 2022
Air pollution endangers human health and sustainable socio-economic development, especially in urban agglomeration (UA). The Chinese government has implemented a series of policies and standards to improve air quality.
Chuanwu Zhao, Yaozhong Pan, Yongjia Teng, Muhammad Fahad Baqa, Wei Guo   +4 more
doaj   +1 more source