Results 201 to 210 of about 1,087,010 (389)

CSF-Net: Cross-Modal Spatiotemporal Fusion Network for Pulmonary Nodule Malignancy Predicting [PDF]

arXiv
Pulmonary nodules are an early sign of lung cancer, and detecting them early is vital for improving patient survival rates. Most current methods use only single Computed Tomography (CT) images to assess nodule malignancy. However, doctors typically make a comprehensive assessment in clinical practice by integrating follow-up CT scans with clinical data.
arxiv  

Nudix Hydrolase 13 Impairs the Initiation of Colorectal Cancer by Inhibiting PKM1 ADP‐Ribosylation

Advanced Science, Volume 12, Issue 13, April 3, 2025.
This study identified NUDT13 as a roadblock in the progression from colorectal adenoma to CRC, and revealed that NUDT13 stabilizes PKM1 protein by reducing the PARylation that is catalyzed by PARP1, thereby reprogramming the metabolic propensity of CRC cells.
Jinlong Lin, Yixin Yin, Jinghua Cao, Bingxu Zou, Kai Han, Yufan Chen, Siyu Li, Cijun Huang, Jiewei Chen, Yongrui Lv, Shuidan Xu, Dan Xie, Fengwei Wang   +12 more
wiley   +1 more source

A Mitochondria‐Targeted Biomimetic Nanomedicine Capable of Reversing Drug Resistance in Colorectal Cancer Through Mitochondrial Dysfunction

Advanced Science, Volume 12, Issue 13, April 3, 2025.
Chemoresistance and metastasis are the main obstacles to the clinical success of anticancer treatment and are responsible for most cancer deaths in CRC. This study develops a sequentially targeted and mitochondrion‐dysfunctional nanodrug (OXA@Exo‐RD) that simultaneously enhances drug concentration and potency in the targeted organelle to overcome ...
Xiaohui Wang, Zhiyuan Xu, Jian Wang, Chunrong Wu, Lin Zhang, Chengyuan Qian, Yang Luo, Yanjuan Gu, Wing‐Tak Wong, Debing Xiang   +9 more
wiley   +1 more source

Condensate Halos in Condensation Frosting

Advanced Science, Volume 12, Issue 14, April 10, 2025.
The freezing of supercooled water drops on cold solid surfaces is an interfacial phase‐change phenomenon accompanied by complex heat and mass transfer yet remains partly understood. By combining optical and thermal imaging techniques, the study scrutinizes the formation, growth, and fading of condensate halos consisting of massive small droplets around
Songyuan Zhen, Haoyan Feng, Shiji Lin, Yakang Jin, Zhigang Li, Xu Deng, Elmar Bonaccurso, Longquan Chen   +7 more
wiley   +1 more source

DARNet: Dual Attention Refinement Network with Spatiotemporal Construction for Auditory Attention Detection [PDF]

arXiv
At a cocktail party, humans exhibit an impressive ability to direct their attention. The auditory attention detection (AAD) approach seeks to identify the attended speaker by analyzing brain signals, such as EEG signals. However, current AAD algorithms overlook the spatial distribution information within EEG signals and lack the ability to capture long-
arxiv  

An Improved Spatiotemporal Fusion Approach Based on Multiple Endmember Spectral Mixture Analysis. [PDF]

Sensors (Basel), 2019
Liu W, Zeng Y, Li S, Pi X, Huang W.
europepmc   +1 more source

4D-ACFNet: A 4D Attention Mechanism-Based Prognostic Framework for Colorectal Cancer Liver Metastasis Integrating Multimodal Spatiotemporal Features [PDF]

arXiv
Postoperative prognostic prediction for colorectal cancer liver metastasis (CRLM) remains challenging due to tumor heterogeneity, dynamic evolution of the hepatic microenvironment, and insufficient multimodal data fusion. To address these issues, we propose 4D-ACFNet, the first framework that synergistically integrates lightweight spatiotemporal ...
arxiv  

The GhWL1‐GhH1‐GhGA2OX1 Transcriptional Module Regulates Cotton Leaf Morphology

Advanced Science, EarlyView.
This study identified GhWL1 as a key gene involved in regulating leaf development through analysis of a T‐DNA insertion mutant. The GhWL1‐GhH1 complex is shown to positively regulate GhGA2OX1 by directly binding to its promoter, thereby establishing the GhWL1‐GhH1‐GhGA2OX1 module as a critical pathway in leaf development.
Jingjing Zhan, Xiaoshuang Zhang, Ye Wang, Hang Zhao, Yu Chu, Peng Wang, Yanli Chen, Xi Wei, Wenqiang Qin, Menghan Liu, Jie Kong, Fuguang Li, Xiaoyang Ge   +12 more
wiley   +1 more source

Immune and Angiogenic Profiling of Mesenchymal Stem Cell Functions in a Subcutaneous Microenvironment for Allogeneic Islet Transplantation

Advanced Science, EarlyView.
With emphasis on a diabetic state, this study highlights the role of mesenchymal stem cells (MSCs) in enhancing vascularization and modulating immune responses within a subcutaneous platform for cell transplantation for type 1 diabetes (T1D). Comprehensive profiling of MSC‐induced angiogenic and immune responses, provides insight into the role of MSCs ...
Jocelyn Nikita Campa‐Carranza, Simone Capuani, Ashley L. Joubert, Nathanael Hernandez, Tommaso Bo, Octavio I. Sauceda‐Villanueva, Marzia Conte, Letizia Franco, Marco Farina, Gabrielle E. Rome, Yitian Xu, Junjun Zheng, Lissenya B. Argueta, Jean A. Niles, Fotis Nikolos, Corrine Ying Xuan Chua, Shu‐Hsia Chen, Joan E. Nichols, Norma S. Kenyon, Alessandro Grattoni   +19 more
wiley   +1 more source

Simultaneous Detection of Neural Activity and Temperature in Photothermal Neural Stimulation

Advanced Science, EarlyView.
Photothermal neuromodulation technology faces limitations in understanding its mechanisms and effects on cellular behavior due to the difficulty of directly measuring temperature changes at the cell interface during optical stimulation of neurons. To overcome this challenge, ultrasensitive, transparent temperature sensors integrated with low‐noise ...
Duhee Kim, Jee Woong Lee, Seoyoung Kang, Woongki Hong, Jungha Lee, Hyuk‐Jun Kwon, Jae Eun Jang, Luke P. Lee, Hongki Kang   +8 more
wiley   +1 more source