Results 221 to 230 of about 1,087,010 (389)

NKX2‐5/LHX1 and UHRF1 Establishing a Positive Feedback Regulatory Circuitry Drives Esophageal Squamous Cell Carcinoma through Epigenetic Dysregulation

Advanced Science, EarlyView.
The study identifies a positive feed‐forward loop that intertwines DNA methylation regulator UHRF1 with Homeobox genes‐NKX2‐5/LHX1 via UMRs as a critical driver of ESCC. Pharmacological inhibition of UHRF1 and DNMT activity inhibits ESCC growth, which may represent a promising therapeutic approach to treat ESCC patients dependent on NKX2‐5/LHX1/UHRF1 ...
Xukun Li, Dandan Fan, Yong Li, Jian Yuan, Wanyuan Sun, Qinghao Zhu, Ling Qi, Xueling Wu, Jiahui Cai, Tongyang Gong, Ning Zhao, Jianzhong Su, Zhihua Liu, Hongyan Chen   +13 more
wiley   +1 more source

Genetics‐Based Targeting Strategies for Precise Neuromodulation

Advanced Science, EarlyView.
In this Review, the fundamental principles and implementation protocols of genetics‐based precision neuromodulation are first introduced. Then, wireless and low‐invasive strategies based on nano‐transducing materials are highlighted, along with a dissection and analysis of the strengths and weaknesses of representative studies.
Yuyuan He, Zhidong Wei, Jianda Xu, Fei Jin, Tong Li, Lili Qian, Juan Ma, Weiying Zheng, Negar Javanmardi, Ting Wang, Kangjian Sun, Zhang‐Qi Feng   +11 more
wiley   +1 more source

Physical Graph-Based Spatiotemporal Fusion Approach for Process Fault Diagnosis. [PDF]

ACS Omega
Zhang F, Jin Q, Li D, Zhang Y, Zhu Q.
europepmc   +1 more source

A CLDN18.2‐Targeted Nanoplatform Manipulates Magnetic Hyperthermia Spatiotemporally for Synergistic Immunotherapy in Gastric Cancer

Advanced Science, Volume 12, Issue 16, April 24, 2025.
CLDN18.2 is a highly selective biomarker exposed in gastric cancer. A CLDN18.2‐specific antibody 1D5 conjugated fluorescence‐magnetic nanoparticle is developed for image‐guided precision theragnostics. Under the assistance of sensitive FMI and deep‐penetrating MPI for tracing and timing the optimal nanoparticle dosage, combining α‐PD1 therapy with ...
Xueying Wang, Hui Hui, Jing Han, Ting Guo, Yiding Wang, Lin Meng, Cong Chen, Jie He, Xiaoyong Guo, Fuyu Zhong, Hong Du, Jie Tian, Xiaofang Xing, Yang Du, Jiafu Ji   +14 more
wiley   +1 more source

LIPUS Promotes Calcium Oscillation and Enhances Calcium Dependent Autophagy of Chondrocytes to Alleviate Osteoarthritis

Advanced Science, Volume 12, Issue 16, April 24, 2025.
A non‐invasive and safe physical therapy, low‐intensity pulsed ultrasound (LIPUS) can alleviate osteoarthritis. This study dynamically “visualizes” the invisible mechanical stimuli of LIPUS on living chondrocytes by fluorescence imaging technology in the form of calcium oscillations, confirming LIPUS maintains cartilage homeostasis by promoting ...
Mengtong Guan, Xiaoyu Han, Bo Liao, Wang Han, Lin Chen, Bin Zhang, Xiuqin Peng, Yu Tian, Gongyi Xiao, Xinhe Li, Liang Kuang, Ying Zhu, Dingqun Bai   +12 more
wiley   +1 more source

A Neural Device Inspired by Neuronal Oscillatory Activity with Intrinsic Perception and Decision‐Making

Advanced Science, Volume 12, Issue 12, March 27, 2025.
Inspired by neuronal oscillatory activity, a neural device with intrinsic perception and decision‐making (NDIPD) is proposed. By mimicking neuronal oscillations, it enables perception and decision‐making at five mechanical stimulation points using a single interface.
Congtian Gu, Guoliang Ma, Mengze Zhang, Hu Shen, Liaoyuan Pu, Yanhe Song, Shilong Yan, Dakai Wang, Kaixian Ba, Bin Yu, Zhiwu Han, Luquan Ren   +11 more
wiley   +1 more source

Multi‐Step Assembly of an RNA‐Liposome Nanoparticle Formulation Revealed by Real‐Time, Single‐Particle Quantitative Imaging

Advanced Science, Volume 12, Issue 12, March 27, 2025.
This work uses multi‐color fluorescence imaging to dissect the dynamic self‐assembly of RNA‐Liposome complexes. The single‐particle, real‐time imaging data enables detailed modeling of this multi‐stage process, from RNA adsorption to higher‐order cluster assembly, across many different formulations and preparatory conditions.
Michael C. Chung, Hector R. Mendez‐Gomez, Dhruvkumar Soni, Reagan McGinley, Alen Zacharia, Jewel Ashbrook, Brian Stover, Adam J. Grippin, Elias J. Sayour, Juan Guan   +9 more
wiley   +1 more source

Localized Sound‐Integrated Display Speaker Using Crosstalk‐Free Piezoelectric Vibration Array

Advanced Science, EarlyView.
To approach multisensory integration of speaker‐integrated OLED displays, this study investigates localized sound emission in display panel speakers by examining crosstalk‐free diaphragm vibrations and enhanced frequency response through multi‐arrayed piezoelectric exciters.
Inpyo Hong, Su Seok Choi
wiley   +1 more source

Real-Time Volume-Rendering Image Denoising Based on Spatiotemporal Weighted Kernel Prediction. [PDF]

J Imaging
Xu X, Xu C, Zhao L.
europepmc   +1 more source

In Situ Control of Reactive Mesogens Alignment During 3D Printing by Two‐Photon Lithography

Advanced Science, EarlyView.
Manipulating material properties at the microscale is crucial for 3D printing of smart microdevices. Two‐photon lithography directly patterns molecular alignment in liquid crystal resists. The polymerization reaction wavefront along the writing path induces an easy‐axis for the mesogenic moieties.
Tiziana Ritacco, Alfredo Mazzulla, Michele Giocondo, Gabriella Cipparrone, Pasquale Pagliusi   +4 more
wiley   +1 more source