Results 81 to 90 of about 7,813 (265)

AND‐Logic‐Gated Aptamer Switch for Precise Targeting and Regulation of RNA G‐Quadruplexes

Angewandte Chemie, EarlyView.
An AND‐logic‐gated aptamer switch enables tumor‐selective activation of RNA G‐quadruplex (rG4)‐targeting function. By combining cell‐surface recognition and intracellular redox sensing, the system achieves precise regulation of disease‐relevant RNA structures exclusively in tumor cells, with minimal off‐target effects in normal cells, offering a ...
Dan Wang, Ying Feng, Chun Kit Kwok
wiley   +2 more sources

Transverse Patterns in Nonlinear Optical Resonators

, 2003
The book is devoted to the formation and dynamics of localized structures (vortices, solitons) and extended patterns (stripes, hexagons, tilted waves) in nonlinear optical resonators such as lasers, optical parametric oscillators, and photorefractive ...
Sanchez-Morcillo, Victor J., Staliunas, Kestutis   +1 more
core   +1 more source

Engineering Neuronal Network Connectivity Through Precise and Scalable Electrical Modulation

Advanced Science, EarlyView.
This study presents a scalable all‐electrical method for precise neuronal‐circuit reconfiguration based on high‐density microelectrode arrays. By employing biologically inspired plasticity rules, targeted connectivity changes were successfully induced and quantified across diverse neuronal preparations.
Sreedhar S. Kumar, Yannaël Bossard, Rachel Sava, Tobias Gänswein, Lorenca Sadiraj, Jean‐Samuel Dupré, Manuel Schröter, J. Gray Camp, Fernando Cardes, Julian Bartram, Andreas Hierlemann   +10 more
wiley   +1 more source

Decoding Undesirable Inflammatory Responses of Nucleic Acid‐Delivering Lipid Nanoparticles

Advanced Science, EarlyView.
Lipid nanoparticles (LNPs) enable efficient nucleic acid delivery, but their immunogenicity is a double‐edged sword. This review explores LNP‐driven innate and adaptive immunity, covering lipid components, endosomal escape, and nucleic acid sensing.
Ruimin Hu, Yin Dou, Chenwen Li, Yuying Mu, Huiying Ouyang, Wenhao Shen, Jianxiang Zhang   +6 more
wiley   +1 more source

Extreme Nonlinear Optics in a Femtosecond Enhancement Cavity

, 2011
Intrinsic to the process of high-order harmonic generation is the creation of plasma and the resulting spatiotemporal distortions of the driving laser pulse.
A. Cingöz, A. E. Siemgman, D. C. Yost, J. Ye, T. K. Allison   +4 more
core   +1 more source

T‐Cell Exhaustion in the Tumor Microenvironment: Subcellular Dysfunction, Pan‐Cancer Characteristics, and Therapeutic Interventions

Advanced Science, EarlyView.
This study elucidates the mechanisms of subcellular multidimensional collapse in exhausted T cells. By specifically targeting the nucleus, mitochondria, and endoplasmic reticulum, strategic interventions can effectively remodel the compromised organelle network. This integrated approach drives comprehensive T cell resuscitation, ultimately establishing
Mingxing Wang, Wanhui Dong, Jian Chen, Zhangjie Zhou, Shujuan Fu, Tingting Wu, Haiyan Jiang, Zhiying Wang, Zhixian Zhong, Yi Zhong   +9 more
wiley   +1 more source

Phase reduction approach to synchronization of spatiotemporal rhythms in reaction-diffusion systems

, 2014
Reaction-diffusion systems can describe a wide class of rhythmic spatiotemporal patterns observed in chemical and biological systems, such as circulating pulses on a ring, oscillating spots, target waves, and rotating spirals. These rhythmic dynamics can
Kawamura, Yoji, Nakao, Hiroya, Yanagita, Tatsuo   +2 more
core   +2 more sources

Synergistic Probe Combining Lysosome Anchoring and Tumor Defense System Targeting for Precise Tumor Visualization

Advanced Science, EarlyView.
A new generation of high‐precision fluorescent probes based on the lysosomal characteristics in tumor metabolic reprogramming and overexpressed tumor markers. The probe (CN‐D‐GGT) selectively label cancer cells in co‐culture systems and distinguish tumor lesions from inflamedand normal tissues in vivo, enabling precise tumor imaging.
Yang Shen, Jiawei Li, Ruixi Yi, Ling Shi, Wei Li, Sulai Liu, Lin Yuan   +6 more
wiley   +1 more source

Superlattice Architectures for Advancing Photothermal Catalysis: Mechanisms and Applications

Advanced Science, EarlyView.
This paper provides a timely overview of superlattice architectures in photothermal catalysis, with a systematic review on mechanisms at both atomic and macroscopic scales in different processes, challenges, and future opportunities. ABSTRACT Photothermal catalysis has emerged as a powerful strategy to complement photocatalysis by harnessing full ...
Yuzhao Wu, Xiaoguang Duan, Haijun Chen, Hongqi Sun, Jinqiang Zhang, Shaobin Wang   +5 more
wiley   +1 more source

Phaselocked patterns and amplitude death in a ring of delay coupled limit cycle oscillators

, 2004
We study the existence and stability of phaselocked patterns and amplitude death states in a closed chain of delay coupled identical limit cycle oscillators that are near a supercritical Hopf bifurcation.
A. A. Brailove, A. T. Winfree, Abhijit Sen, G. B. Ermentrout, George L. Johnston, Martin Golubitsky, Michael F. Crowley, Ramana Dodla, S. H. Strogatz, Willis E. Lamb, Jr., Y. Kuramoto, Y. Kuramoto, Y. Kuramoto   +12 more
core   +1 more source