Results 41 to 50 of about 139,792 (250)

The current dimension of social policy in the EU countries as a guideline for reforms in Ukraine

open access: yesУкраїнський соціум, 2023
The article presents modern approaches to measuring and possibly conducting a comparative analysis of the effectiveness of social policy in individual countries with the help of global and regional special indicator systems and global indices of well ...
Khaustov V. K.
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Statistical Assessment of The Implementation of Socio-Economic Development Strategies of The Republic of Uzbekistan in the Context of Digital Transformation

open access: yesСтатистика и экономика, 2022
Purpose of the study. The main purpose of the article is to conduct a statistical assessment of the implementation of strategies for the socio-economic development of the Republic of Uzbekistan using an innovative methodology based on the use of digital ...
B. A. Begalov, I. E. Zhukovskaya
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

COMPARATIVE ANALYSIS OF SPECIAL ASSESMENT OF WORKING CONDITIONS AND CERTIFICATION OF WORKPLACES

open access: yesRUDN Journal of Ecology and Life Safety, 2016
А comparative analysis of special assessment of working conditions and certification of workplaces was conducted. It was revealed that the aborted procedure of certification of workplaces allows control of all production factors affecting on employers ...
G A Kulieva, M I Kochanova, D V Lunev
doaj  

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

open access: yesFEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure   +3 more
wiley   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

open access: yesFEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson   +6 more
wiley   +1 more source

Salmonella lipopolysaccharide‐containing supported lipid bilayers as platforms to study bacteriophage interactions

open access: yesFEBS Letters, EarlyView.
We present robust protocols for the preparation of supported lipid bilayers (SLBs) incorporating either Salmonella smooth LPS or outer membrane vesicles (OMVs). We use a combination of quartz crystal microbalance with dissipation (QCM‐D) and fluorescence microscopy to both characterize the SLBs of various compositions and to probe their interactions ...
Hudson P. Pace   +6 more
wiley   +1 more source

Research on Rub-Impact Loads Response of Ship Shafting

open access: yesPolish Maritime Research, 2018
The anti-impact ability of shafting affects stability and security of the ship power transmission directly. Moreover, it also cannot be ignored that the rub-impact loads have influence on the torsion vibration of ship shafting.
Dong Liang-xiong   +2 more
doaj   +1 more source

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