Results 81 to 90 of about 19,768,754 (339)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Introduction to the Special Issue
Political Analysis, 2004 Welcome to the special issue ofPolitical Analysisdedicated to Bayesian methods. We hope that you enjoy the varied and interesting contributions herein featuring Bayesian statistical methods. For many people in empirical political science, Bayesian statistics seems like a weird offshoot of probability that surfaces occasionally in journals and books but
openaire +5 more sources
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
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Futures, 2019 This special issue analyses and reflects on socio-technical futures as core elements in innovation processes and their governance. The special issue assembles twelve contributions that draw on several lines of research mobilizing concepts developed in ...
Kornelia Konrad, K. Böhle
semanticscholar +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
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Crop Residue Management Challenges: A Special Issue Overview
Agronomy Journal, 2019 The amount of crop residues that can be sustainability removed is highly variable and is a function of many factors including the soil, climatic, and plant characteristics.
D. Clay +7 more
semanticscholar +1 more source
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
Special Issue Dedicated to Li Zehou on His 90th Birthday – Ethics and the Beauty of Human Becoming
Asian Studies, 2020 The present issue of the journal Asian Studies is dedicated to Li Zehou, one of the greatest contemporary Chinese philosophers. It was compiled as a part of the celebration of his 90th birthday, which will take place on June 13 2020.
Jana S. Rošker
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FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source