Results 71 to 80 of about 4,923,427 (296)

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

A review of the Knowledge Management Centre: conducted for the Economic and Human Development Department, City of Cape Town [PDF]

, 2012
Following a study of the resources and services of the Knowledge Management Centre (KMC) of the Economic and Human Development Department (EHD) and a survey of a sample of users and potential users, the conclusion is that the KMC is NOT operating in a ...
Underwood, Peter G, Smith, Gretchen
core  

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

University proceedings. Volga region. Social sciences

Известия высших учебных заведений. Поволжский регион: Общественные науки
Background. Low-quality medical equipment used in the provision of medical care can endanger not only health, but also human life. This determines the public danger of such attacks on human life and health. The detection of these crimes is complicated by
V.N. Semelev
doaj   +1 more source

Specialized Knowledge Representation and the Parameterization of Context [PDF]

Frontiers in Psychology, 2016
Though instrumental in numerous disciplines, context has no universally accepted definition. In specialized knowledge resources it is timely and necessary to parameterize context with a view to more effectively facilitating knowledge representation, understanding, and acquisition, the main aims of terminological knowledge bases.
Faber, Pamela, León-Araúz, Pilar
openaire   +3 more sources

Less-is-more effects without the recognition heuristic [PDF]

, 2010
Inferences consistent with “recognition-based” decision-making may be drawn for various reasons other than recognition alone. We demonstrate that, for 2-alternative forced-choice decision tasks, less-is-more effects (reduced performance with additional ...
Beaman, Charles Philip, Frosch, Caren Antoinette, McCloy, Rachel Ann, Smith, Philip Twitchell   +3 more
core  

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Участие специалиста при проведении допроса

Проблеми Законності, 2016
Статья посвящена исследованию отдельных вопросов участия специалиста при проведении такого распространенного следственного (розыскного) действия, как допрос. Анализируются процессуальные нормы, регламентирующие участие специалиста в допросе.
Вікторія Олегівна Яремчук
doaj   +1 more source

International conference on software engineering and knowledge engineering: Session chair [PDF]

, 2018
The Thirtieth International Conference on Software Engineering and Knowledge Engineering (SEKE 2018) will be held at the Hotel Pullman, San Francisco Bay, USA, from July 1 to July 3, 2018.
Bosu, Michael Franklin
core  

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source