Results 61 to 70 of about 82,762 (302)

Tumor B‐cell infiltration in platinum‐treated advanced muscle‐invasive urothelial carcinoma

Molecular Oncology, EarlyView.
Bladder tumors with higher pretreatment memory B‐cell infiltration were linked to longer survival after cisplatin chemotherapy, but not carboplatin. These tumors also showed more organized immune structures (tertiary lymphoid structures) and a shared pro‐inflammatory B‐cell‐rich community, suggesting that memory B cells may help identify patients most ...
Konrad Stawiski, Júlia Perera‐Bel, Alejo Rodriguez‐Vida, Nuria Juanpere, Jihyun Lee, Daniel E. Michaud, Jennifer L. Guerriero, Kent W. Mouw, Aristotelis Bamias, Filipe L. F. Carvalho, Joaquim Bellmunt   +10 more
wiley   +1 more source

ZW4864‐mediated inhibition of the β‐catenin/BCL9/BCL9L complex reveals therapeutic potential in bladder cancer

Molecular Oncology, EarlyView.
BCL9 and BCL9L drive bladder cancer progression by enhancing β‐catenin signaling, promoting proliferation, migration, invasion, and organoid growth. Genetic depletion of BCL9(L) suppresses malignant phenotypes, while pharmacological disruption of the β‐catenin/BCL9(L) complex with ZW4864 inhibits canonical Wnt signaling and tumor‐associated cellular ...
Roland Kotolloshi, Mandy Berndt‐Paetz, Eileen Lerner, Gregoire Najjar, Anca Azoitei, Krishna Pal Singh, Shailendra Kumar Gupta, Olaf Wolkenhauer, Cagatay Günes, Otmar Huber, Marc‐Oliver Grimm, Daniel Steinbach   +11 more
wiley   +1 more source

The Concept and Essence of Specialised Knowledge Used in Smuggling Investigation

Bulletin of Kharkiv National University of Internal Affairs
The article substantiates that in the theory of forensic science the concept of “special knowledge” has a broad and narrow meaning. The expediency of using this term in a narrow sense is determined by the context of its use (for example, in terms of a ...
Yu. Yu. Kovalov
doaj   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source

Decreased cold‐sensing function of the transient receptor potential channel TRPM8 from tailed amphibians

FEBS Open Bio, EarlyView.
Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao, Daiki Kobayashi, Shogo Hori, Osamu Saitoh   +3 more
wiley   +1 more source

Knowledge of attention/deficit hyperactivity disorder (ADHD) – a comparison of pre-service teachers in primary and special education in Germany [PDF]

, 2015
Background Given that the majority of children with attention deficit hyperactivity disorder (ADHD) attend regular classroom settings in Germany, it is necessary for teachers to be well prepared to provide these children appropriate care and education ...
Hannah Sophia Lammers, Yumi Lee, Evelin Witruk   +2 more
core   +1 more source

Application of specialised knowledge in the investigation of collaborative activitу: practical aspects

Bulletin of Kharkiv National University of Internal Affairs
The article substantiates the position that in the course of investigation of collaboration activities, it is important to involve competent persons in criminal proceedings.
V. O. Husieva, S. M. Beseda
doaj   +1 more source

WAYS OF PROTECTING THE RIGHTS OF PERSONS INVOLVED IN CRIMINAL PROCEEDINGS AT THE STAGE OF APPROVAL BY THE PROSECUTOR OF THE ACT ENDING THE PRELIMINARY INVESTIGATION WITH SENDING THE CASE TO COURT [PDF]

Legal Bulletin
Despite the presence of a fairly developed system of ways to protect human rights and freedoms, in criminal proceedings there is a high risk of their violation.
VOLKOV A.A.
doaj   +1 more source

Modern understanding of criminalistic tactics: concepts, features, subject and tasks

Теорія і практика правознавства, 2020
The article is devoted to the study of the problems of modern understanding of criminalistic tactics, its subject and tasks. The scientific approaches to the studied concepts of «criminalistic tactics» was analyzed.
Віктор Михайлович Шевчук
doaj   +1 more source

The skills required for transition to university and study in biological sciences: A student perspective

FEBS Open Bio, EarlyView.
Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley   +1 more source