Results 71 to 80 of about 174,710,578 (276)
Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation
Molecular Oncology, EarlyView.How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim +11 more
wiley +1 more source
Cooperation between special libraries and other types of libraries [PDF]
, 1969 "The student of special libraries struggles first with defining them. Special libraries exist in every environment, hence if I define them too broadly, there is no group other than themselves with which they may interact.
Shank, Russell
core
['CONSTITUTIVE MODELLING OF SANDS UNDER MONOTONIC LOADING']
Journal of Mountain Area Research, 2023 Muhammad Safdar +4 more
doaj +1 more source
Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer
Molecular Oncology, EarlyView.Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba +5 more
wiley +1 more source
Other title: For Your Files: Policy Letter / Special Education Administration
, 1991 "January 7, 1991." "TO: All Directors of Special Education." "FROM: Betty M. Weithers.""The delivery of Special Education services within program models variously described as "integrated" or "inclusive" is generating much discussion.
Weithers, Betty.
core +1 more source