Results 61 to 70 of about 377,362 (305)
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Analysis of the effectiveness of existing pond to accommodate storm water runoff in UTHM [PDF]
, 2018 Rapid development within UTHM campus has changed the existing earth surface from pervious to impervious layer thus increasing the surface runoff. This study describe the application of XP SWMM software in determining the effectiveness of existing pond to
Mohd Yusoff, Mohd Azlan +2 more
core +1 more source
FEBS Letters, EarlyView.Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley +1 more source
Electrolytic purification of water [PDF]
, 2006 This thesis develops the concept of an in situ electrolytic processor, a machine with electrochemical functions that purifies aqueous fluids at the point of production, whether from a bore water supply or effluent from a tannery.
Mathieson, Grant Alexander
core
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Scientific and Technical Tools for Enhancement of Special Treatment Devices
Вестник войск РХБ защитыHighlights- nowadays it is impossible to maintain contaminated vehicles and equipment in special decontamination centers nearthe battle line due to far-ranging precision weapons and drones;- promising on-board sets and special treatment devices should be
V. V. Mahniboroda +2 more
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Development of a Mathematical Ground Water Model [PDF]
, 1972 The development of a mathematical model for study of water management and budget of the irrigated area of the Snake River Fan in eastern Idaho was initiated in May, 1970.
DeSonneville, J.L.J.
core
Solution of the municipal waste water treatment efficiency in Strážske [PDF]
Acta Montanistica Slovaca, 2005 A special and long lasting problem in the Slovak republic in the substantial hydraulical overloading of some wastewater treatment plants. Because their technology of treatment is inconvenient and the quality of treated water is not according to the ...
Eugen Kovaľ +2 more
doaj
Study on Water Gradient Utilization and Zero Emission Technology in IGCC Power Plant
Zhongguo dianli, 2019 In the first IGCC power plant in China, there are some problems in the operation process such as the water drainage process is not reasonable and the coal gasification and sulfur containing wastewater is difficult to deal with. In view of these problems,
Huoqiang WU +6 more
doaj +1 more source