Selective Targeting of Tip Endothelial Cells as a Therapeutic Strategy for Tumor Angiogenesis
Doppel protein is selectively expressed in tip endothelial cells within the tumor vasculature, where it promotes tip cell motility and stabilizes the tip cell phenotype. Targeting Doppel with monoclonal antibodies disrupts this stabilization, impairs angiogenic sprouting, and reduces tumor angiogenesis, offering a selective and druggable switch for ...
Byoungmo Kim +16 more
wiley +1 more source
Enabling and hindering aspects of the i²TransHealth e-health intervention for transgender and gender diverse people in Germany: a qualitative process evaluation. [PDF]
Schmidt F +5 more
europepmc +1 more source
Simplification of Skills in England: an interim assessment of progress on implementing the recommendations in Simplification of Skills in England [PDF]
core
A microfluidic electrochemical biosensor enables sensitive and specific detection of antibodies associated with vaccine‐induced immune thrombotic thrombocytopenia (VITT) and heparin‐induced thrombocytopenia (HIT). The platform uses two antigen targets— platelet factor 4 (PF4) and cross‐linked‐PF4 (c‐PF4)—and microliter volumes of patient sera to ...
Diana F. Cedillo‐Alcantar +8 more
wiley +1 more source
Professional Roles, Skills and Advanced Educational Programs of Breast Cancer Nurses: A Scoping Review. [PDF]
D'Alessandro L +9 more
europepmc +1 more source
The establishment at Community level of a policy and a plan of priority actions for the development of an information services market. Communication from the Commission together with a draft decision. COM (87) 360 final/2, 2 September 1987 [PDF]
core
Hungry for Knowledge: Octopamine Signaling Regulates Hunger‐Enhanced Olfactory Learning
Researchers demonstrate that hunger state facilitates both aversive and appetitive olfactory learning. Two distinct octopamine signaling pathways are involved in aversive or appetitive memory formation in the hunger state. And, hunger state also facilitates the formation of both types of memories via an evolutionarily conserved norepinephrine (the ...
Huijuan Zhao +14 more
wiley +1 more source
Turning crisis into potential: Leveraging the skills of forced Ukrainian migrant women in Poland. [PDF]
Castillo-Sánchez JE +2 more
europepmc +1 more source
OPTRACE: Optical Imaging–Guided Transplantation and Tracking of Cells in the Mouse Brain
OPTRACE establishes an optical, two‐step platform for intracerebral cell therapy. Transparent glass pipettes enable real‐time, image‐guided delivery, while multiplex genetic labeling with two‐photon and bioluminescence readouts supports longitudinal single‐cell tracking and host–graft dynamics.
Jinghui Wang +10 more
wiley +1 more source
Prevalence of eye care service utilisation and associated factors among healthcare professionals in Gondar city, northwest Ethiopia, 2024: community-based cross-sectional study. [PDF]
Bekele MM +5 more
europepmc +1 more source

