Results 51 to 60 of about 9,088 (236)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Odor-regulated oviposition behavior in an ecological specialist

Nature Communications, 2023
Colonization of a novel ecological niche can require, or be driven by, evolution of an animal’s behaviors promoting their reproductive success. We investigated the evolution and sensory basis of oviposition in Drosophila sechellia, a close relative of ...
Raquel Álvarez-Ocaña, Michael P. Shahandeh, Vijayaditya Ray, Thomas O. Auer, Nicolas Gompel, Richard Benton   +5 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Characterizing the phylogenetic specialism–generalism spectrum of mammal parasites [PDF]

, 2018
The distribution of parasites across mammalian hosts is complex and represents a differential ability or opportunity to infect different host species. Here, we take a macroecological approach to investigate factors influencing why some parasites show a ...
S. Huang, P. Pappalardo, Dallas, T.A., Nunn, C.L., Nunn, C. L., Davies, T. J., Farrell, M.J., Farrell, M. J., Pappalardo, P., Poulin, R., Park, A. W., Schmidt, J. P., Huang, S.; id_orcid, J. P. Schmidt, T. J. Davies, Park, A.W., Stephens, P. R., M. J. Farrell, R. Poulin, Huang, S., J. M. Drake, P. R. Stephens, Drake, J.M., Schmidt, J.P., Stephens, P.R., Davies, T.J., C. L. Nunn, Dallas, T. A., A. W. Park, T. A. Dallas, Drake, J. M.   +30 more
core   +1 more source

Developing leadership qualities in students of the Military Academy during the study of specialism-related disciplines using a foreign language [PDF]

, 2020
The purpose of the study was to identify what influence the leadership program delivered in English and using the specialism content has on the Military Academy students’ leadership qualities.
Ivanchenko, Ievgeniia A., Bachynska, Nataliia Ya., Heorhiiev, Vasyl M., Masliy, Oleh M., Babak, Vasyl I.   +4 more
core   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Residential child care in England

Scottish Journal of Residential Child Care, 2016
This article provides a summary of the current context for residential child care in England. It records continually increasing outcomes as evidenced in a new set of Quality Standards by a new inspection framework.
Jonathan Stanley
doaj   +1 more source

Habitat shifts in the evolutionary history of a Neotropical flycatcher lineage from forest and open landscapes

BMC Evolutionary Biology, 2008
Background Little is known about the role ecological shifts play in the evolution of Neotropical radiations that have colonized a variety of environments.
Christidis Les, Rheindt Frank E, Norman Janette A   +2 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source