Results 41 to 50 of about 108,831,459 (268)

SPG4 and Dementia: Expanding the Clinical Spectrum

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Hereditary spastic paraplegia (HSP) is a group of disorders characterized by progressive spasticity and lower limb weakness, with mutations in SPG4/SPAST being the most common cause. Detailed studies and clinical and molecular comparisons across different populations are missing.
Emanuele Panza, Arun Meyyazhagan, Eliseo Picchi, Gustavo Ribas, Ingrid Faber, Ryosuke Miyamoto, Preethi Basavaraju, Paolo Eusebi, Haripriya Kuchi Bhotla, Mario Stasi, Fabrizio Gaudiello, Francesco Patti, Filippo Maria Santorelli, Marcondes Cavalcante França Jr, José Luiz Pedroso, Orlando Graziani Povoas Barsottini, Hélio Afonso Ghizoni Teive, Peter Henry St George‐Hyslop, Toshitaka Kawarai, Antonio Orlacchio   +19 more
wiley   +1 more source

Screening Routine Clinical Notes for Epilepsy Surgery Candidates Using Large Language Models

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Epilepsy surgery is severely underutilized despite proven efficacy, with substantial under‐referral of eligible patients in routine clinical practice. This study evaluated the potential role of large language models (LLMs) as decision‐support tools for screening unstructured clinical notes to identify epilepsy surgery candidates and ...
Uriel Fennig, Nadav Amir, Maya Schiller, Roni Loebenstein, Johnatan Nissan, Marina Boxer, Shany Guly Gofrit, Gal Goshen, Sándor Beniczky, Nicola Maggio   +9 more
wiley   +1 more source

The trends of mortality, aetiologies and risk factors of lower respiratory infections in Saudi Arabia from 1990 to 2021: results from the global burden of disease study 2021

Journal of Health, Population and Nutrition
Background Lower respiratory tract infections (LRIs) are the fourth leading cause of death globally, affecting all age groups and leading to over 2 million deaths annually. Saudi Arabia faces a significant burden from LRIs, affecting more than 15% of the
Majed Ramadan, Rbab Bajunaid, Jood Abdulhafeez Alansari, Hala Yusef, Rawiah A. Alsiary   +4 more
doaj   +1 more source

Incidence of non-syndromic orofacial cleft during the COVID-19 pandemic in Saudi Arabia

BMC Public Health, 2023
Objectives This is the first national study to investigate the incidence of non-syndromic oro-facial clefts (NSOFC) and Pierre-Robin-Sequence in Saudi Arabia over the Covid-19 pandemic period.
Heba Jafar Sabbagh, Sultan Musaad Alghamdi, Fatma Dawood Abdulhameed, Reema Mahdi Alhussain, Najla Sulaiman Alrejaye, Latifa Yousef AlGudaibi, Bahauddin Ibraheem Sallout, Badi Shoaib Albaqawi, Eman Abdulbaset Alnamnakani, Lougin Khalid Brekeit, Mona Tala Alsharif, Ali Bakr Alshaikh, Manal Ibrahim Almalik, Abdullah Jameel Aburiziza, Norah Suliman Al Soqih, Faisal Ali Alqhtani, Bushra Musaad Alghamdi, Asalah Khalid Alraddadi, Aziza Johar Aljohar, Osama Adel Basri, Rana Abdullah Alamoudi   +20 more
doaj   +1 more source

Onasemnogene Abeparvovec in Patients With SMA: Interim Results of the RESTORE Registry in Japan

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective There are limited real‐world data regarding the safety and effectiveness of onasemnogene abeparvovec (OA; Zolgensma) infusion, a one‐time gene replacement therapy, for Japanese patients with spinal muscular atrophy (SMA). We aimed to improve understanding of the real‐world outcomes for OA in Japan.
Kayoko Saito, Kamal Benguerba, Ken Tsuchida, Kazushige Yazawa, Isao Tsumiyama, Hiromitsu Kayama, Sandra P. Reyna, Farid Khan, Richard S. Finkel   +8 more
wiley   +1 more source

Actual areas of improvement of regulatory and organizational support for the training of specialists with higher legal education at institutions of higher education of the system of the Ministry of Internal Affairs of Ukraine

Bulletin of Kharkiv National University of Internal Affairs, 2022
The regulatory and organizational principles of reforming legal education at the current stage of the state’s development have been studied. The final content of the Concept of the Development of Legal Education, approved by the Committee of the Verkhovna Rada of Ukraine on Education, Science and Innovation, and the new editions of the standards of ...
openaire   +3 more sources

Quantitative MRI Uncovers Subtle Cortical Damage in Myelin Oligodendrocyte Glycoprotein Antibody‐Associated Disease

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To determine whether myelin‐sensitive quantitative MRI reveals microstructural abnormalities in normal‐appearing cortex (NACtx) in myelin oligodendrocyte glycoprotein antibody–associated disease (MOGAD), indicating that conventional MRI underestimates remission residual cortical injury.
Valentina Camera, Agnese Tamanti, Silvia Messina, Nicola Dall'Osto, Teresa Maltempo, Stefano Ziccardi, Matteo Foschi, Maria Grazia Piscaglia, Diana Ferraro, Francesco Crescenzo, Francesca Rossi, Albulena Bajrami, Sabrina Marangoni, Damiano Marastoni, Francesca Benedetta Pizzini, Maria Isabel Leite, Roberta Magliozzi, Patrick Waters, Massimiliano Calabrese, Jacqueline Palace, Ruth Geraldes   +20 more
wiley   +1 more source

Improving the training of specialists to ensure the security of the information infrastructure of the internal affairs authorities

Bezopasnost informacionnyh tehnology
The departmental personnel training system of the Ministry of Internal Affairs of Russia has significant experience in training specialists in various educational programs in the field of information security. Over the past decade, due to various factors, significant changes have taken place in this area, particularly in its state regulation based ...
Viktor S. Gorbatov, Aleksandr S. Erdniev
openaire   +2 more sources

AU Office of International Affairs' Vital Role in Coordinating Support Services for International Students

, 2021
Among the available services and assistance provided to AU International students by numerous University units or sections, the International Affairs Office's important functions is also to coordinate and render ready assistance through co-ordination,

core  

Temporal Interference Stimulation of Centromedian‐Parafascicular Complex in Disorders of Consciousness: A Pilot Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Treatment of disorders of consciousness (DoC) remains a major clinical challenge, and noninvasive, targeted modulation of deep brain structures has emerged as a promising therapeutic strategy. We aimed to evaluate the feasibility/safety and preliminary effects of thalamic temporal interference stimulation (TIS) targeting centromedian‐
Gengyao Hu, Changgeng Song, Dianwei Wu, Xiaoqian Niu, Jianmin Hao, Lijuan Liu, Xiaogang Kang, Wen Jiang   +7 more
wiley   +1 more source