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Specialized metabolism in St John's wort
Current Opinion in Plant BiologyThe specialized metabolism of St. John's wort, Hypericum perforatum L., is a key focus in medicinal plant research due to its hallmark bioactive compounds hyperforin and hypericin. Known for its traditional medicinal uses dating back to ancient times, St. John's wort is currently used for mild depression therapy.
Song Wu, Evangelos C. Tatsis
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Genomic Signatures of Specialized Metabolism in Plants
Science, 2014Specialized Evolution Many plants make chemical compounds that are potentially of use to humans, but their evolutionary histories are unknown. Chae et al. (p.
Lee, Chae +3 more
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Combinatorial Transcriptional Control of Plant Specialized Metabolism
Trends in Plant Science, 2018Plants produce countless specialized compounds of diverse chemical nature and biological activities. Their biosynthesis often exclusively occurs either in response to environmental stresses or is limited to dedicated anatomical structures. In both scenarios, regulation of biosynthesis appears to be mainly controlled at the transcriptional level, which ...
Maite, Colinas, Alain, Goossens
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Progestin metabolism: Special reference to estrogenic pathways
Metabolism, 1965Abstract Synthetic progestational agents are diovided into 2 main groups, i.e., the “19-nor” compounds and the so-called “substituted” progestins. Each has a different metabolic pathway. For example, the “19-nor” compounds are converted into estrogens in vivo, whereas the “substituted” progestins are not.
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Special focus: Mammalian circadian rhythms and metabolism
Trends in Endocrinology & Metabolism, 2012Mammalian circadian rhythms are regulated by a series of interconnected transcriptional auto-regulatory feedback loops, that control the circadian cycle. Recent studies have revealed an interesting connection between the clock machinery and regulators of cellular metabolism; disruption of circadian rhythms may influence the development of pathological ...
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The multicellular compartmentation of plant specialized metabolism
Current Opinion in Plant BiologyThe phenomenon of multicellular compartmentation in biosynthetic pathways has been documented for only a limited subset of specialized metabolites, despite its hypothesized significance in facilitating plant survival and adaptation to environmental stress.
Xiaofeng, Shen +4 more
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Editorial – Regulation of Metabolism Special Issue
The Plant Journal, 2023Alisdair, Fernie, Lee, Sweetlove
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Decoding plant specialized metabolism: new mechanistic insights
Trends in Plant ScienceSecondary metabolite (SM) production provides biotic and abiotic stress resistance and enables plants to adapt to the environment. Biosynthesis of these metabolites involves a complex interplay between transcription factors (TFs) and regulatory elements, with emerging evidence suggesting an integral role for chromatin dynamics.
Qianqian Li +4 more
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Metabolomics in cancer research and emerging applications in clinical oncology
Ca-A Cancer Journal for Clinicians, 2021Daniel R Schmidt +2 more
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