Results 11 to 20 of about 2,389,185 (200)

Validated bioanalysis of oxylipins confirms specialized pro-resolving mediator formation in vitro and in vivo. [PDF]

J Lipid Res
Specialized pro-resolving mediators (SPM) are di-or trihydroxylated polyunsaturated fatty acids with potent inflammation-resolving features. SPM typically occur at lower concentrations than classical pro-inflammatory eicosanoids, making their detection ...
Hofstetter RK, Werner M, Schädel P, Wichmann-Costaganna M, Fischer K, Bruggink V, Meyer KPL, Peltner L, Günther K, Bachmann V, Engelbrecht H, Gutjahr C, Perkowski B, Griebel G, Bal NB, Ueberschaar N, Jordan PM, Werz O.   +17 more
europepmc   +2 more sources

Specialized Pro-Resolving Mediators at the Ocular Surface: Biosynthesis, Mechanisms, and Therapeutic Potential. [PDF]

Biology (Basel)
Specialized pro-resolving mediators (SPMs) are endogenous lipid mediators that actively orchestrate the resolution of inflammation rather than relying solely on broad suppression of inflammatory signaling.
Gandhi S, Shokravi A, Buhrow S, Balas M.
europepmc   +2 more sources

Subgingival Microbiome and Specialized Pro-Resolving Lipid Mediator Pathway Profiles Are Correlated in Periodontal Inflammation [PDF]

, 2021
Failure of resolution pathways in periodontitis is reflected in levels of specialized pro-resolving lipid mediators (SPMs) and SPM pathway markers but their relationship with the subgingival microbiome is unclear.
Lisha Zhu, Ruoxing Li, Li, Ruoxing, Zhu, Lisha, Tribble, Gena D, Thomas E. Van Dyke, W. Jim Zheng, Brittney Ferguson, Krishna Rao Maddipati, Lee, Chun-Teh, Angelov, Nikola, Van Dyke, Thomas E, Nikola Angelov, Maddipati, Krishna Rao, Chun-Teh Lee, Gena D. Tribble, Ferguson, Brittney, Zheng, W Jim   +17 more
core   +1 more source

Specialized Pro-resolving Mediators: Resolving Inflammation and Restoring Bone [PDF]

, 2023
Periodontitis is a chronic inflammatory disease characterized by gingival inflammation and loss of periodontal ligament attachment, which if severe enough can lead to the irreversible destruction of surrounding alveolar bone.
Tran, Amber, Raglin, Amber, Bilbrey, Carrie Nichole   +2 more
core   +1 more source

Pro-resolving lipid mediator lipoxin A4 attenuates neuro-inflammation by modulating T cell responses and modifies the spinal cord lipidome [PDF]

, 2021
The chronic neuro-inflammatory character of multiple sclerosis (MS) suggests that the natural process to resolve inflammation is impaired. This protective process is orchestrated by specialized pro-resolving lipid mediators (SPMs), but to date, the role ...
Silvia Martina Tietz, Alessandro Leuti, Valerio Chiurchiu, Serhan, Charles N, Tietz, Silvia Martina, Haghayegh Jahromi, Neda, Norris, Paul C, Schouten, Marijn, de Vries, Helga E., Neda Haghayegh Jahromi, Helga de Vries, Enzmann, Gaby, Charles N Serhan, Jahromi, Neda Haghayegh, Chiurchiù, Valerio, Gaby Enzmann, Kooij, Gijs, van der Pol, Susanne M. A., Engelhardt, Britta, van der Pol, Susanne M A, Britta Engelhardt, Norris, Paul C., Serhan, Charles N., Claudio Derata Troletti, Kamermans, Alwin, Leuti, Alessandro, Paul C Norris, de Vries, Helga E, Alwin Kamermans, Derada Troletti, Claudio, Gijs Kooij, Susanne M.A. van der Pol, Marijn Schouten,   +32 more
core   +2 more sources

Distinct Profiles of Specialized Pro-Resolving Lipid Mediators and Corresponding Receptor Gene Expression In Periodontal Inflammation [PDF]

, 2020
Polyunsaturated fatty acid-derived specialized pro-resolving lipid mediators (SPMs) play an important role in modulating inflammation. The aim of the study was to compare profiles of SPMs, SPM related lipid mediators and SPM receptor gene expression in ...
Zhu, Lisha, Van Dyke, Thomas E, Bokka, Nishantha R, Maddipati, Krishna Rao, Ayilavarapu, Srinivas, Chen, Wanqi, Lee, Chun-Teh, Ferguson, Brittney, Angelov, Nikola, Weltman, Robin, Zheng, W Jim   +10 more
core   +1 more source

Anti-inflammatory celastrol promotes a switch from leukotriene biosynthesis to formation of specialized pro-resolving lipid mediators

, 2021
The pentacyclic triterpenoid quinone methide celastrol (CS) from Tripterygium wilfordii Hook. F. effectively ameliorates inflammation with potential as therapeutics for inflammatory diseases.
Lorkowski S., Zhang K., Kretzer C., Bilancia R., Potenza M., Jordan P. M., Hofstetter R. K., Gerstmeier J., Pace S., Chen X., Borner F., Wang W., Rossi A., Newcomer M. E., Fischer D., Gilbert N. C., Werz O.   +16 more
core   +3 more sources

Inflammation resolution and specialized pro-resolving lipid mediators in chronic rhinosinusitis

, 2023
Introduction: In chronic rhinosinusitis (CRS), a complex pathophysiology results from varied pro-inflammatory stimuli but is consistently characterized by classic cellular, molecular, and microbial alterations.
Peyton Z. Robinson, Daniel N. Frank, Ramakrishnan, Vijay R., Vijay R. Ramakrishnan, Frank, Daniel N., Robinson, Peyton Z.   +5 more
core   +1 more source

Altered Tissue Specialized Pro-Resolving Mediators in Chronic Rhinosinusitis

, 2021
Current literature implicates arachidonic acid-derived leukotrienes and prostaglandins in the pathogenesis of chronic rhinosinusitis. However, other omega-3 and omega-6 derived lipid mediators, such as specialized pro-resolving mediators (SPMs), may also
Kroehl, Miranda E., Armstrong, Michael, Vickery, Thad W., Reisdorph, Nichole A., Ramakrishnan, Vijay R., Robertson, Charles E., Kofonow, Jennifer M., Frank, Daniel N.   +7 more
core   +1 more source

Role of Specialized Pro-Resolving Mediators in Modifying Host Defense and Decreasing Bacterial Virulence

, 2021
Bacterial infection activates the innate immune system as part of the host’s defense against invading pathogens. Host response to bacterial pathogens includes leukocyte activation, inflammatory mediator release, phagocytosis, and killing of bacteria.
Julianne M. Thornton, Kingsley Yin
core   +1 more source