Results 111 to 120 of about 1,155,432 (434)

Impact of in-house specialty pharmacy on access to novel androgen axis inhibitors in men with advanced prostate cancer [PDF]

, 2020
Introduction: Novel androgen axis inhibitors are standard of care treatments in advanced prostate cancer. The billed amounts for these medications are often very high, which may create significant financial toxicity for patients and lead to delays in ...
Binder, Adam, Driscoll, Anna, Handley, MD, MBA, Nathan, Henry, Siobhan, Kelly, DO, W. Kevin   +4 more
core   +1 more source

KMT2A degradation is observed in decitabine‐responsive acute lymphoblastic leukemia cells

Molecular Oncology, EarlyView.
We demonstrate that decitabine (DEC) not only degrades the DNA methyltransferase DNMT1 but also the leukemic driver lysine methyltransferase KMT2A likely due to structural similarity of the DNA‐binding CXXC domains. DEC influences KMT2A downstream processes and synergizes with menin inhibitor revumenib (REV) to decrease leukemic cell proliferation, and
Luisa Brock, Lina Benzien, Sandra Lange, Maja Huehns, Alexandra Runge, Catrin Roolf, Anett Sekora, Gudrun Knuebel, Hugo Murua Escobar, Christian Junghanss, Anna Richter   +10 more
wiley   +1 more source

Breaking the Barriers to Specialty Care: Practical Ideas to Improve Health Equity and Reduce Cost - Helping Patients Engage in Specialty Care [PDF]

, 2016
Tremendous health outcome inequities remain in the U.S. across race and ethnicity, gender and sexual orientation, socio-economic status, and geography—particularly for those with serious conditions such as lung or skin cancer, HIV/AIDS, or cardiovascular
Chris Carlson, Jared Sholk, Jennifer Nanni, Kyle Peterson, Lauren A. Smith, Neeraja Bhavaraju   +5 more
core  

Polyfunctional CD8+CD226+RUNX2hi effector T cells are diminished in advanced stages of chronic lymphocytic leukemia

Molecular Oncology, EarlyView.
CD226+CD8+ T cells express elevated levels of RUNX2, exhibit higher proliferation capacity, cytokines and cytolytic molecules expression, and migratory capacity. In contrast, CD226−CD8+ T cells display an exhausted phenotype associated with the increased expression of co‐inhibitory receptors and impaired effector functions.
Maryam Rezaeifar, Shima Shahbaz, Anthea C. Peters, Spencer B. Gibson, Shokrollah Elahi   +4 more
wiley   +1 more source

Career choices of the first seven cohorts of JCU MBBS graduates: producing generalists for regional, rural and remote northern Australia

Rural and Remote Health
Introduction: Generalism in the health workforce has been established as an important strategy to address health workforce maldistribution. Thus, to best serve the medical needs of northern Australia, the James Cook University (JCU) College of Medicine ...
Torres Woolley, Sarah Larkins, Tarun Sen Gupta   +2 more
doaj   +1 more source

MOTIVATION FOR TRADITIONAL STUDY AND E-LEARNING OF DESIRED AND UNDESIRED SPECIALTIES

Anthropological Researches and Studies, 2020
Objectives. It is important to establish if motivation for studying a desired specialty is more long-lasting, stimulating e-learning and job-related performance than motivation for studying an undesired specialty.
Lambri YOVKOV
doaj   +1 more source

A PROFILE OF THE SPECIALTY FOOD RETAILING INDUSTRY IN THE EASTERN U.S. [PDF]

This study investigated product introductions, marketing and distribution patterns among specialty food retailers in the eastern U. S. Based on 547 responses to a mailed survey, the results portray specialty food retailers as an extremely diverse group ...
Cheng, Hsiang-Tai, Crabtree, David, Kezis, Alan S., Peavey, Stephanie R.   +3 more
core   +1 more source

Response to neoadjuvant chemotherapy in early breast cancers is associated with epithelial–mesenchymal transition and tumor‐infiltrating lymphocytes

Molecular Oncology, EarlyView.
Epithelial–mesenchymal transition (EMT) and tumor‐infiltrating lymphocytes (TILs) are associated with early breast cancer response to neoadjuvant chemotherapy (NAC). This study evaluated EMT and TIL shifts, with immunofluorescence and RNA sequencing, at diagnosis and in residual tumors as potential biomarkers associated with treatment response.
Françoise Derouane, Jérôme Ambroise, Cédric van Marcke, Mieke Van Bockstal, Martine Berlière, Christine Galant, Hélène Dano, Médina Lougué, Elena Benidovskaya, Guy Jerusalem, Vincent Bours, Claire Josse, Jérôme Thiry, Aurélie Daumerie, Caroline Bouzin, Cyril Corbet, François P. Duhoux   +16 more
wiley   +1 more source

A new approach for detecting scientific specialties from raw cocitation networks [PDF]

arXiv, 2008
We use a technique recently developed by Blondel et al. (2008) in order to detect scientific specialties from author cocitation networks. This algorithm has distinct advantages over most of the previous methods used to obtain cocitation "clusters", since it avoids the use of similarity measures, relies entirely on the topology of the weighted network ...
arxiv  

Career specialty choices of UK medical graduates of 2015 compared with earlier cohorts: questionnaire surveys

Postgraduate medical journal, 2018
Objective To report the career specialty choices of UK medical graduates of 2015 one year after graduation and to compare these with the choices made at the same postgraduate stage by previous cohorts.
T. Lambert, Fay Smith, M. Goldacre
semanticscholar   +1 more source