Results 41 to 50 of about 896,578 (389)
FoxO1 signaling in B cell malignancies and its therapeutic targeting
FEBS Letters, EarlyView.FoxO1 has context‐specific tumor suppressor or oncogenic character in myeloid and B cell malignancies. This includes tumor‐promoting properties such as stemness maintenance and DNA damage tolerance in acute leukemias, or regulation of cell proliferation and survival, or migration in mature B cell malignancies.
Krystof Hlavac +3 more
wiley +1 more source
中西医结合护理, 2022 This paper explored the establishment practice of a specialized Traditional Chinese Medicine(TCM) nursing outpatient service model, and summarize the characteristics of advanced practical service in TCM nursing outpatient service.
LIANG Qiuhui (梁秋会) +7 more
doaj +1 more source
Diphthamide synthesis is linked to the eEF2‐client chaperone machinery
FEBS Letters, EarlyView.The diphthamide modification of eukaryotic translation elongation factor 2 (eEF2) is important for accurate protein synthesis. We addressed the potential coordination of de novo eEF2 synthesis with simultaneous or subsequent diphthamide modification. Our work reveals that the co‐chaperones Hgh1 and Cpr7, which are known to support folding of nascent ...
Lars Kaduhr +4 more
wiley +1 more source
Are You Applying to More Than One Specialty? [PDF]
, 2019 Although the majority of U.S. medical students predominantly apply to only one specialty, some apply to more than one. When it comes to emergency medicine (EM), applicants may apply to additional specialties due to several reasons: being international ...
Cheaito, Mohamad Ali +8 more
core
Functional variation among LPMOs revealed by the inhibitory effects of cyanide and buffer ions
FEBS Letters, EarlyView.This study addresses the inhibition of lytic polysaccharide monooxygenases (LPMOs) by cyanide and explains how and why the magnitude of observed inhibitory effects depends on the way LPMO reactions are setup and on the type of LPMO. Enzymes known as lytic polysaccharide monooxygenases (LPMOs) are mono‐copper polysaccharide‐degrading peroxygenases that ...
Ole Golten +10 more
wiley +1 more source
INNOVATION MANAGERS FOR THE COUNTRY’S TECHNOLOGICAL SOVEREIGNTY
Стратегические решения и риск-менеджмент, 2023 The article substantiates the authors’ position, supported by empirical data, on the sharp increase in the intellectual intensity of managerial activities and on the transformation of the managerial profession into one of the most complex, gaining ...
L. D. Gitelman +3 more
doaj +1 more source
FEBS Letters, EarlyView.We present the first solution structure of the Ca2+‐depleted LETM1 F‐EF‐hand through a D676A/N678A Ca2+ binding‐deficient mutant, revealing a closed hydrophobic cleft caused by a unique F1‐helix pivot. The apo LETM1 F‐EF‐hand exhibits regiospecific hot and cold unfolding, sensitivity to physiological pH changes and potential for promiscuous heterotypic
Qi‐Tong Lin +2 more
wiley +1 more source
Acta Médica Costarricense, 2012 Introducción: La decisión de estudiar medicina depende de múltiples factores incluyendo aspectos internos (personales) y otros externos al individuo. Conocer estos factores puede ser útil para la administración del plan de estudios de la carrera y para ...
Juan Ignacio Padilla-Cuadra +2 more
doaj
Quantification of BERT Diagnosis Generalizability Across Medical Specialties Using Semantic Dataset Distance [PDF]
arXiv, 2020 Deep learning models in healthcare may fail to generalize on data from unseen corpora. Additionally, no quantitative metric exists to tell how existing models will perform on new data. Previous studies demonstrated that NLP models of medical notes generalize variably between institutions, but ignored other levels of healthcare organization. We measured
arxiv