Results 51 to 60 of about 1,035,278 (359)

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

Decisión de estudiar medicina: Factores determinantes y elección de la especialidad Decision to Study Medicine: Determinants and Specialty Choice

open access: yesActa Médica Costarricense, 2012
Introducción: La decisión de estudiar medicina depende de múltiples factores incluyendo aspectos internos (personales) y otros externos al individuo. Conocer estos factores puede ser útil para la administración del plan de estudios de la carrera y para ...
Juan Ignacio Padilla-Cuadra   +2 more
doaj  

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

open access: yesFEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson   +7 more
wiley   +1 more source

The nomenclature of scientific specialties and the new model of award of academic degrees: Russian experience

open access: yesПравоприменение, 2019
The subject of the article is legal regulation of award of academic degrees in Russia after the reform that let universities and scientific organization award academic degrees independently, without centralized state control over this process.The main ...
Svetlana V. Narutto
doaj   +1 more source

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Specialty preferences of final year students studying physical therapy in Peshawar

open access: yesRehman Journal of Health Sciences, 2020
Introduction: Choosing a specialty after graduation plays an important role in the life of a student. However, little is known about students' preferences about selection of specialties in physical therapy students in developing countries.
Shehermaan Shadab Amin   +6 more
doaj   +1 more source

Knowledge of Driving Vehicle Licensing Agency guidelines among NHS doctors:A multicentre observational study [PDF]

open access: yes, 2015
Objectives: Over half of the UK population holds a driver's licence. The DVLA have produced guidelines to ensure drivers with medical conditions drive safely. Doctors should ensure that patients are given appropriate information and advice if they have a
Garnham, Jack   +7 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Transformation of subject training of physics teacher during a change in the educational format [PDF]

open access: yesИзвестия Саратовского университета. Новая серия: Физика
Background and Objectives: The change in the format of education in the main areas of training in higher educational institutions of the country, carried out after the signing of the Bologna Convention in 2003, marked a significant change in the practice
Burova, Tatiana G.
doaj   +1 more source

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