Dual native G‐quadruplex folding is associated with chromatin looping at the MYC locus
FEBS Open Bio, EarlyView.BG4‐detectable G‐quadruplex (G4) in HaCaT and NHEK keratinocytes identified folded and unfolded G4s enriched at promoters/TSSs and active enhancers, whereas unfolded G4s also overlapped weak/poised enhancers. At MYC–PVT1, 3C‐qPCR detected enhancer–promoter looping only when G4s were simultaneously folded at both regulatory elements under native ...
Dieila Giomo de Lima +7 more
wiley +1 more source
Heterotropic regulation and negative homotropic cooperativity
FEBS Open Bio, EarlyView.We identified a structural module common to some proteins that couple negative cooperativity with heterotropic regulation, two features that rarely coexist. These proteins are ring‐like and present an ordered asymmetry whereby noncontacting subunits are symmetric, and their tertiary structure differs from that of contacting subunits.
Veronica Morea +5 more
wiley +1 more source
Student Identity and Geography Matter for Specialty Choice in Family Medicine. [PDF]
Fam Med, 2023 Blomgren A, Rodríguez JE.
europepmc +1 more source
What Adds Value in Specialty Coffee? Managerial Implications from Hedonic Price Analysis of Central and South American E-Auctions [PDF]
We analyze price and quality information at the procurement level in the specialty coffee supply chain using data from small and large volume e-auctions.
Hoehn, John P. +2 more
core
Personality Traits and Specialty Choice Among Oman Medical Specialty Board Residents
, 2017 IntroductionUnderstanding factors that determine the choice of a specialty among junior doctors are crucial for career counseling and candidates selection. Most studies focused on working hours, income and other lifestyle factors.
H. Al Sinawi, S. Al Huseini, M. Al Alawi
core +1 more source
FEBS Open Bio, EarlyView.Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia +9 more
wiley +1 more source
Residents' reasons for specialty choice: influence of gender, time, patient and career.
, 2010 OBJECTIVE This study examined reasons for specialty choice among Swiss residents (post graduate doctors training in specialties). METHODS In 2006, a questionnaire was sent to 8626 Swiss residents registered in postgraduate medical training programmes to ...
Siegrist M +3 more
core +1 more source
Comparative assessment of crystallographic and cryo‐EM models in the Protein Data Bank
FEBS Open Bio, EarlyView.Raw data obtained by X‐ray crystallography or cryo‐EM result in experimental maps, ultimately fitted by atomic models. Although the physical principles are different, the final results can be viewed, compared, and evaluated in the same way. With cryogenic electron microscopy (cryo‐EM) on track to surpass X‐ray crystallography as the preferred method ...
Alexander Wlodawer +7 more
wiley +1 more source
Influencing Factors of Future Specialty Choice for Undergraduate Medical Students: An Updated Experience from the UAE. [PDF]
Avicenna J Med, 2023 Al Zubaidi A +6 more
europepmc +1 more source