Results 81 to 90 of about 1,722,879 (239)
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
FEBS Open Bio, EarlyView.Evolutionary analysis across 32 placental mammals identified positive selection at residues H148 and W149 in the immune receptor FcγR1. Ancestral reconstruction combined with molecular dynamics simulations reveals how these mutations may influence receptor structure and dynamics, providing insight into the evolution of antibody recognition and immune ...
David A. Young +7 more
wiley +1 more source
FEBS Open Bio, EarlyView.Abruptly changing from aerobic to anaerobic conditions (sudden anaerobization) induced growth inhibition and a significant increase in intracellular labile ferrous iron in the aerotolerant anaerobe Amphibacillus xylanus. We found that free flavins mediate efficient electron transfer from NADH to ferric iron under anaerobic conditions, suggesting that ...
Shinya Kimata +13 more
wiley +1 more source
Cutaneous Melanoma Drives Metabolic Changes in the Aged Bone Marrow Immune Microenvironment
Aging and Cancer, EarlyView.Melanoma, the deadliest form of skin cancer, increasingly affects older adults. Our study reveals that melanoma induces changes in iron and lipid levels in the bone marrow, impacting immune cell populations and increasing susceptibility to ferroptosis.
Alexis E. Carey +12 more
wiley +1 more source
DiversityHabitat fragmentation and reduction in the Cerrado are the primary threats to this biome’s biodiversity. The amount of habitat in the landscape has been proposed as the sole predictor variable for species richness in fragmented areas, potentially ...
Ednaldo Cândido Rocha +2 more
doaj +1 more source
Project Chariot - Phase III: Progress Report [PDF]
, 1960 This is a preliminary report and is NOT FOR PUBLICATIONBotanical investigations of the Cape Thompson - Ogotoruk Creek region of northwest Alaska were initiated in May, 1959 by the University of Alaska under contract with the United States Atomic ...
Johnson, R.E. +2 more
core
Phytogenic mounds (nebkhas): effect of Tricomaria usillo on sand entrapment in central-west of Argentina [PDF]
, 2016 Nebkhas, developed by the trapping of sand within the body of a plant, were studied in the Médanos Grandes system, arid central Argentina, during the springs of 2009-2010.In this system, formed by megadunes and overlapping dunes, nebkhas dynamism was ...
Martinez Carretero, Eduardo Enrique +1 more
core +1 more source
Predictive Ability of Plasma p‐tau217 for β‐Amyloid Status: A Prospective Multicenter Study
Annals of Clinical and Translational Neurology, EarlyView.ABSTRACT Objective Plasma tau phosphorylated at threonine 217 (p‐tau217) measured with fully automated platforms has shown high accuracy for Alzheimer's disease (AD) diagnosis, but real‐world multicenter data remain limited. We aimed to validate the diagnostic performance of p‐tau217 for identifying AD pathology in a real‐world multicenter cohort ...
Miquel Massons +33 more
wiley +1 more source
Individual-area relationship best explains goose species density in wetlands.
PLoS ONE, 2015 Explaining and predicting animal distributions is one of the fundamental objectives in ecology and conservation biology. Animal habitat selection can be regulated by top-down and bottom-up processes, and is mediated by species interactions.
Yong Zhang +4 more
doaj +1 more source
Automated Discovery of Relationships, Models, and Principles in Ecology
Frontiers in Ecology and Evolution, 2020 Ecological systems are the quintessential complex systems, involving numerous high-order interactions and non-linear relationships. The most used statistical modeling techniques can hardly accommodate the complexity of ecological patterns and processes ...
Pedro Cardoso +14 more
doaj +1 more source