Results 271 to 280 of about 69,851 (348)

Serum p‐tau217 Is a Prognostic Indicator of Cognitive Impairment in Idiopathic REM Sleep Behavior Disorder

open access: yesAnnals of Neurology, EarlyView.
Objective Assess the performance of serum phosphorylated tau 217 (p‐tau217) and neurofilament light chain (NfL) in predicting risk of cognitive impairment or phenoconversion to dementia in individuals with iRBD. Methods We measured serum p‐tau217 and NfL levels by electrochemiluminescence across 4 polysomnographically confirmed iRBD cohorts (n = 300 ...
Shijun Yan   +7 more
wiley   +1 more source

Fibril Structure of Desiccation‐Protective Tardigrade Protein CAHS‐8

open access: yesAngewandte Chemie, EarlyView.
We present the atomic structure of the fibril formed by an intrinsically disordered protein that has been shown to be responsible for remarkable environmental stress in tardigrades. X‐ray crystallography reveals a unique mechanism of fibril assembly whereby a single helix forms a stable, antiparallel coiled‐coil dimer, which then assembles into a ...
Anas Malki   +6 more
wiley   +2 more sources

Topographical Variation of Iron‐Rimmed Lesions in the Multiple Sclerosis Brain and Spinal Cord: A Neuropathological Study

open access: yesAnnals of Neurology, EarlyView.
Paramagnetic‐rim lesions are a novel diagnostic marker in multiple sclerosis (MS) and are associated with poor prognosis due to their link with chronic inflammation and disease progression. Analyzing 46 postmortem MS cases, researchers found no iron rims in 67 white matter and 85 grey matter spinal cord lesions, despite most being active.
Marco Pisa   +10 more
wiley   +1 more source

Dynamic Confinement Approach for High Metal Loading Single‐Atom Catalysts Based on Covalent Organic Frameworks

open access: yesAngewandte Chemie, EarlyView.
We introduced a new synthetic strategy for the preparation of high metal loading crystalline single‐atom catalysts based on covalent organic frameworks with atomically distributed Pd ions and metal contents of up to 22.2 wt%. Theoretical simulations reveal that the crystalline framework dynamically confines Pd atoms between different binding sites ...
Kyung Seob Song   +11 more
wiley   +2 more sources

An integrative approach clarifies species delimitation and biogeographic history of <i>Debregeasia</i> (Urticaceae). [PDF]

open access: yesPlant Divers
Kipkoech A   +8 more
europepmc   +1 more source

Revisiting Incomplete Tissue‐Level Reperfusion Following Successful Thrombectomy for Acute Ischemic Stroke

open access: yesAnnals of Neurology, EarlyView.
Among patients with acute ischemic stroke achieving successful large vessel recanalization (defined as expanded Thrombolysis in Cerebral Infarction [eTICI ≥2b]), incomplete tissue‐level reperfusion, distinct from visually identifiable distal occlusion on digital‐subtraction angiography, remains a significant challenge.
Yue Qiao   +4 more
wiley   +1 more source

Engineering Ultrasound Contrast Agents for Targeted Therapeutics: A Theranostic Approach to Drug Delivery, Gene Therapy, and Immunomodulation

open access: yesAdvanced NanoBiomed Research, EarlyView.
Ultrasound contrast agents, including microbubbles and nanobubbles, transform imaging and targeted therapy through precise engineering of size, shell composition, and surface properties. This review explores how these innovations enable tissue‐specific delivery, enhance therapeutic efficacy, and extend applications from vascular imaging to tumor ...
Ashkan Seza   +2 more
wiley   +1 more source

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