Results 121 to 130 of about 7,005,640 (397)

Tumor clusters with divergent inflammation and human retroelement expression determine the clinical outcome of patients with serous ovarian cancer

Molecular Oncology, EarlyView.
Analysis of treatment‐naïve high‐grade serous ovarian carcinoma (HGSOC) and control tissues for ERVs, LINE‐1 (L1), inflammation, and immune checkpoints identified five clusters with diverse patient recurrence‐free survivals. An inflammation score was calculated and correlated with retroelement expression, where one novel cluster (Triple‐I) with high ...
Laura Glossner, Markus Eckstein, Christoph Mark, Matthias W. Beckmann, Arndt Hartmann, Pamela L. Strissel, Reiner Strick   +6 more
wiley   +1 more source

Two near-chromosomal-level genomes of globally-distributed Macroascomycete based on single-molecule fluorescence and Hi-C methods

Scientific Data
Discinaceae holds significant importance within the Pezizales, representing a prominent group of macroascomycetes distributed globally. However, there is a dearth of genomic studies focusing on this family, resulting in gaps in our understanding of its ...
Wei Liu, Xiaofei Shi, Yingli Cai, Wenhua Sun, Peixin He, Jesus Perez-Moreno, Dong Liu, Fuqiang Yu   +7 more
doaj   +1 more source

Nutrient levels and trade-offs control diversity in a serial dilution ecosystem

, 2020
Microbial communities feature an immense diversity of species and this diversity is linked with outcomes ranging from ecosystem stability to medical prognoses. Yet the mechanisms underlying microbial diversity are under debate.
Abel, Abrams, Adler, Aldén, Armstrong, Barton, Basan, Bernstein, Bienhold, Brown,, Chang, Chesson, Chesson, Dakos, Demoling, Egli, Erez, Flourie, Goldford, Goyal, Hubbell, Hutchinson, Jost, Kassen, Kelsic, Kim, Kovárová-Kovar, Ladau, Leibold, Lendenmann, Lendenmann, Lendenmann, Lenski, Levin, Lloyd-Price, MacArthur, Mittelbach, Monod, Murrell, Münster, Palmer, Posfai, Ptacnik, Robinson, Rosenzweig, Scherer, Scott, Smith, Smith, Smits, Stein, Stewart, Taur, Thingstad, Tilman, Tilman, van Elsas, Waide, Wandrey, Weigel, Wortel, Yurtsev   +61 more
core   +1 more source

Beyond digital twins: the role of foundation models in enhancing the interpretability of multiomics modalities in precision medicine

FEBS Open Bio, EarlyView.
This review highlights how foundation models enhance predictive healthcare by integrating advanced digital twin modeling with multiomics and biomedical data. This approach supports disease management, risk assessment, and personalized medicine, with the goal of optimizing health outcomes through adaptive, interpretable digital simulations, accessible ...
Sakhaa Alsaedi, Xin Gao, Takashi Gojobori   +2 more
wiley   +1 more source

A comparison of species diversity estimators

Population Ecology, 1999
AbstractAlthough having been much criticized, diversity indices are still widely used in animal and plant ecology to evaluate, survey, and conserve ecosystems. It is possible to quantify biodiversity by using estimators for which statistical characteristics and performance are, as yet, poorly defined.
David Mouillot, Alain Leprêtre
openaire   +2 more sources

Bioengineering facets of the tumor microenvironment in 3D tumor models: insights into cellular, biophysical and biochemical interactions

FEBS Open Bio, EarlyView.
The tumor microenvironment is a dynamic, multifaceted complex system of interdependent cellular, biochemical, and biophysical components. Three‐dimensional in vitro models of the tumor microenvironment enable a better understanding of these interactions and their impact on cancer progression and therapeutic resistance.
Salma T. Rafik, Deniz Bakkalci, Alexander J. MacRobert, Umber Cheema   +3 more
wiley   +1 more source

Plant succession on gopher mounds in Western Cascade meadows: consequences for species diversity and heterogeneity [PDF]

, 2008
Pocket gophers have the potential to alter the dynamics of grasslands by creating mounds that bury existing vegetation and locally reset succession. Gopher mounds may provide safe sites for less competitive species, potentially increasing both species ...
Halpern, Charles B., Jones, Chad C., Niederer, Jessica   +2 more
core   +1 more source

Species Diversity--Scale Matters

Science, 2002
The marked gradient in species diversity between the equator (where it is highest) and the poles (where it is lowest) suggests a simple environmental explanation for this phenomenon. However, as Willis and Whittaker point out in their Perspective, the environmental variables driving species diversity are different depending on the size and time
Willis, K, Whittaker, R
openaire   +2 more sources

Comparative single‐cell transcriptomic profiling of patient‐derived renal carcinoma cells in cellular and animal models of kidney cancer

FEBS Open Bio, EarlyView.
We generated and characterized clear cell renal cell carcinoma models using the patient‐derived RCC243 cell line—including cell culture, orthotopic, and metastatic tumors—via single‐cell RNA‐sequencing for comparisons between models and patient tumor datasets.
Richard Huang, Lynn Kee, Alexander Gont, Jalna Meens, Fraser G. Ferens, Meredith S. Irwin, Laurie Ailles, Scott A. Yuzwa, Claire M. Robinson, Michael Ohh   +9 more
wiley   +1 more source

Effects of species diversity on disease risk.

Ecology Letters, 2006
The transmission of infectious diseases is an inherently ecological process involving interactions among at least two, and often many, species. Not surprisingly, then, the species diversity of ecological communities can potentially affect the prevalence ...
F. Keesing, R. Holt, R. Ostfeld
semanticscholar   +1 more source