Results 31 to 40 of about 9,212 (204)
Molecular Oncology, EarlyView.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
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Nauplius, 2018 All species of Brazilian terrestrial isopod known up to date, including references and distribution information, are listed. The list comprises 189 valid species, 135 of which are endemic to the country, 22 are recorded also from other countries in the ...
Ivanklin Soares Campos-Filho +2 more
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New geographical records of Mesembrinellidae (Diptera: Oestroidea) in Mexico
Revista Chilena de Entomología, 2021 Currently, the family Mesembrinellidae has 55 extant species restricted to the Americas. In this study, the distribution of 6 out of 55 species which corresponds to the Mexican species of the family is discussed.
Santiago Jaume-Schinkel
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Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
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Taxonomy, 2023 The location of Israel at the junction of three continents leads to a unique fauna of both Palearctic and Afrotropical zoogeographic origins. Following systematic revisions over the past sixty years and the discovery of new species, the only available ...
Sharon Warburg +5 more
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Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
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Memorias do Instituto Oswaldo Cruz, 2009 The following five new species of Culicoides from Colombia are described, illustrated and placed to subgenus or species group: Culicoides antioquiensis, Culicoides gabrieli, Culicoides inermis, Culicoides micayensis and Culicoides nigrifemur. C. gabrieli
Gustavo R Spinelli +4 more
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Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
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Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
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Nematodes from rocky grassland in Börzsöny Mountains, Hungary [PDF]
Opuscula Zoologica Instituti Zoosystematici et Oecologici Universitatis Budapestinensis, 2011 This paper reports on investigations carried out on soil inhabiting nematodes living in andesitic rock regions ofBörzsöny Mountains. Seventeen species are listed.
Kiss, M.
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