Results 111 to 120 of about 13,050,965 (387)

From omics to AI—mapping the pathogenic pathways in type 2 diabetes

FEBS Letters, EarlyView.
Integrating multi‐omics data with AI‐based modelling (unsupervised and supervised machine learning) identify optimal patient clusters, informing AI‐driven accurate risk stratification. Digital twins simulate individual trajectories in real time, guiding precision medicine by matching patients to targeted therapies.
Siobhán O'Sullivan, Lu Qi, Pierre Zalloua   +2 more
wiley   +1 more source

Specificity of soil-borne pathogens on grain legumes [PDF]

, 2004
Specificity of soil-borne legume pathogens on pea, lupin and faba bean is currently investigated in fields where grain legumes are intensively cultivated.
Bødker, Lars, Jensen, Birgit, Jørnsgaard, Bjarne, Knudsen, Jens Chr., Larsen, John   +4 more
core  

Thermostable neutral metalloprotease from Geobacillus sp. EA1 does not share thermolysin's preference for substrates with leucine at the P1′ position

FEBS Letters, EarlyView.
Knowing how proteases recognise preferred substrates facilitates matching proteases to applications. The S1′ pocket of protease EA1 directs cleavage to the N‐terminal side of hydrophobic residues, particularly leucine. The S1′ pocket of thermolysin differs from EA's at only one position (leucine in place of phenylalanine), which decreases cleavage ...
Grant R. Broomfield, Torsten Kleffmann, David J. Saul, Sigurd M. Wilbanks   +3 more
wiley   +1 more source

Editorial: History of Growth Hormone: Animal to Human

Frontiers in Endocrinology, 2021
Edward O. Reiter, Laurie E. Cohen, Alan D. Rogol   +2 more
doaj   +1 more source

Specificity of Morbillivirus Hemagglutinins to Recognize SLAM of Different Species

Viruses, 2019
Measles virus (MV) and canine distemper virus (CDV) are highly contagious and deadly, forming part of the morbillivirus genus. The receptor recognition by morbillivirus hemagglutinin (H) is important for determining tissue tropism and host range.
Hideo Fukuhara, Yuri Ito, Miyuki Sako, Mizuho Kajikawa, Koki Yoshida, Fumio Seki, Mwila Hilton Mwaba, Takao Hashiguchi, Masa-aki Higashibata, Toyoyuki Ose, Kimiko Kuroki, Makoto Takeda, Katsumi Maenaka   +12 more
doaj   +1 more source

Dynamics of transcription factor binding site evolution [PDF]

, 2015
Evolution of gene regulation is crucial for our understanding of the phenotypic differences between species, populations and individuals. Sequence-specific binding of transcription factors to the regulatory regions on the DNA is a key regulatory ...
Barton, Nicholas H., Paixão, Tiago, Tkačik, Gašper, Tuğrul, Murat   +3 more
core   +6 more sources

Exploring lipid diversity and minimalism to define membrane requirements for synthetic cells

FEBS Letters, EarlyView.
Designing the lipid membrane of synthetic cells is a complex task, in which its various roles (among them solute transport, membrane protein support, and self‐replication) should all be integrated. In this review, we report the latest top‐down and bottom‐up advances and discuss compatibility and complexity issues of current engineering approaches ...
Sergiy Gan, Victoria Scarpelli, Marten Exterkate   +2 more
wiley   +1 more source

Phenotypic landscape inference reveals multiple evolutionary paths to C$_4$ photosynthesis [PDF]

, 2013
C$_4$ photosynthesis has independently evolved from the ancestral C$_3$ pathway in at least 60 plant lineages, but, as with other complex traits, how it evolved is unclear.
Abramoff, Adams, Akyildiz, Aubry, Beebe, Brown, Brown, Bruhl, Bustin, Casati, Cheng, Christin, Christin, Christin, Christin, Christin, Devi, Devi, Edwards, Furbank, Gavrilets, Goldstein, Gowik, Griffiths, Hatch, Hattersley, Hattersley, Heckman, Hibberd, Hill, Holaday, Holaday, Holaday, Hylton, Johnson, Kajala, Keeley, Kennedy, Khoshravesh, Kidwell, Koteyeva, Kozmik, Ku, Ku, Ku, Ku, Langdale, Livak, Lobkovsky, McKown, McKown, Mooers, Moore, Muhaidat, Osborne, P’yankov, Rabiner, Rajendrudu, Rathnam, Rathnam, Rawsthorne, Rawsthorne, Revuz, Rosche, Roweis, Sage, Sage, Sage, Santos, Sayre, Slack, Smith, Steiner, Ueno, Ueno, Vicentini, Vogan, Voznesenskaya, Voznesenskaya, Voznesenskaya, Wasserman, Weinreich, Whibley, Williams, Wilson, Wiludda, Wittkopp, Wright, Zhu   +88 more
core   +3 more sources

Ergothioneine supplementation improves pup phenotype and survival in a murine model of spinal muscular atrophy

FEBS Letters, EarlyView.
Spinal muscular atrophy (SMA) is a genetic disease affecting motor neurons. Individuals with SMA experience mitochondrial dysfunction and oxidative stress. The aim of the study was to investigate the effect of an antioxidant and neuroprotective substance, ergothioneine (ERGO), on an SMNΔ7 mouse model of SMA.
Francesca Cadile, Daniela Ratto, Giorgia Rastelli, Ottavia Eleonora Ferraro, Caterina Temporini, Sunil Kumar, Simona Boncompagni, Paola Rossi, Monica Canepari   +8 more
wiley   +1 more source

Microbial exopolysaccharide production by polyextremophiles in the adaptation to multiple extremes

FEBS Letters, EarlyView.
Polyextremophiles are microorganisms that endure multiple extreme conditions by various adaptation strategies that also include the production of exopolysaccharides (EPSs). This review provides an integrated perspective on EPS biosynthesis, function, and regulation in these organisms, emphasizing their critical role in survival and highlighting their ...
Tracey M Gloster, Ebru Toksoy Öner
wiley   +1 more source