Results 181 to 190 of about 4,755,677 (326)

BMI‐1 modulation and trafficking during M phase in diffuse intrinsic pontine glioma

FEBS Open Bio, EarlyView.
The schematic illustrates BMI‐1 phosphorylation during M phase, which triggers its translocation from the nucleus to the cytoplasm. In cycling cells, BMI‐1 functions within the PRC1 complex to mediate H2A K119 monoubiquitination. Following PTC596‐induced M phase arrest, phosphorylated BMI‐1 dissociates from PRC1 and is exported to the cytoplasm via its
Banlanjo Umaru, Deepak Kumar Mishra, Shiva Senthil Kumar, Hao‐Han Pang, Brendan Devine, Komal Khan, Rachid Drissi   +6 more
wiley   +1 more source

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

Beyond the Choice of What You Put in Your Mouth: A Systematic Mapping Review of Veganism and Vegan Identity. [PDF]

Front Psychol, 2022
Vestergren S, Uysal MS.
europepmc   +1 more source

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source

Cerebral Organoid Research Ethics and Pinning the Tail on the Donkey. [PDF]

Camb Q Healthc Ethics, 2023
McKeown A.
europepmc   +1 more source

Speciesism, anti-speciesism and animal rights

, 2019
Introduced by Ryder in 1970, “speciesism” is defined as a form of discrimination based on species. This concept echoes racism and sexism. First formulated to show the superiority (i.e., the superior rights) that humans attribute to themselves compared to other animals, speciesism then took on board the differences that people attribute to other species.
openaire   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Veganism: an extended theory of planned behavior framework incorporating ethical, environmental, and sociodemographic determinants. [PDF]

Front Nutr
Öneş E, Gençalp C, Avcı G, Sipahi S, Kahrıman M, Yılmaz S, Baş M.   +6 more
europepmc   +1 more source

Are the folk utilitarian about animals? [PDF]

Philos Stud, 2023
Kahane G, Caviola L.
europepmc   +1 more source

"When We're Human": An Intersectional Look at Speciesism and Racism in the Disney Animation Studios Film "The Princess and the Frog" [PDF]

, 2019
Vargas, Grisel
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