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Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

open access: yesFEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel   +4 more
wiley   +1 more source
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Specific Cognitive Abilities at Work

Journal of Personnel Psychology, 2014
Recent findings suggest that the role of specific cognitive abilities in predicting work-related criteria may be critical and may add to the widely demonstrated importance of general mental ability. To summarize and organize these findings, the current paper puts forward two perspectives on the role of specific cognitive abilities in predicting work ...
Stefan Krumm   +2 more
openaire   +3 more sources

GENETICS OF SPECIFIC COGNITIVE ABILITIES

Annual Review of Genetics, 1976
reasoning Space relations Mechanical reasoning Clerical speed and accuracy Language use I: Spelling Language use II: Sentences aReprinted from Reference 119. bp < 0.01. 1961 2.29b 1.39 1.47 1.67 1.36 2.54b 3.64b 3.
J C, DeFries   +2 more
openaire   +2 more sources

A specific calculating ability

Intelligence, 1998
We report two experiments that investigate the calculating strategy used by a low IQ savant to identify prime numbers. Hermelin and O'Connor (1990) had suggested previously that this subject may use a procedure first described by Eratosthenes to detect a prime number, namely, dividing a target number by all primes up to the square root of the target ...
Anderson, M., O'Connor, N., Hermelin, B.
openaire   +1 more source

Familial resemblance for specific cognitive abilities

Behavior Genetics, 1979
Measures of familial resemblance (spouse correlations, regressions of offspring on midparent, single-parent/single-child correlations, and sibling correlations) are presented for members of the two largest ethnic groups tested in the Hawaii Family Study of Cognition.
J C, DeFries   +6 more
openaire   +2 more sources

Factors and primes: a specific numerical ability

Psychological Medicine, 1990
SYNOPSISAn autistic young man and a normal control were asked to factorize numbers and to recognize and generate primes. Both subjects made a similar of errors and employed similar strategies, but they differed markedly in the speeds at which the arithmetical operations were carried out.
B, Hermelin, N, O'Connor
openaire   +2 more sources

Clinical Competence: General Ability or Case-specific?

Advances in Health Sciences Education, 2006
Before the 1970s, research into the development of clinical competence was mainly focused on general problem-solving abilities. The scope of research changed when Elstein and colleagues discovered that individual ability to solve clinical problems varies considerably across cases.
Wimmers, PF   +3 more
openaire   +3 more sources

Assortative marriage for specific cognitive abilities in Korea

Social Biology, 1976
Abstract Age‐adjusted spouse correlations for performance on tests of specific cognitive abilities were substantially higher for couples tested in Korea than for Americans of European or Japanese ancestry tested in Hawaii. It was hypothesized that this greater spouse resemblance in Korea may be due to cultural factors such as the Korean practice of ...
R C, Johnson   +7 more
openaire   +2 more sources

A specific linguistic ability.

American journal of mental retardation : AJMR, 1991
A young man with diagnosed hydrocephalic brain injury was found to be an able linguist. His ability to translate into English from French, German, and Spanish was confirmed to be at a high level, and his capacity to express thoughts and describe scenes in these languages was also verified.
N, O'Connor, B, Hermelin
openaire   +1 more source

Prosodic abilities in children with specific language impairment

Journal of Communication Disorders, 1997
The purpose of this study was to compare the receptive and expressive prosodic abilities of specifically language-impaired children to those of a matched group of control normal-language children. Each subject group consisted of ten 4-year-olds, ten 5-year-olds and ten 6-year-olds. Subjects were administered two instruments which were designed for this
S, Van Der Meulen, P, Janssen, E, Den Os
openaire   +2 more sources

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