Results 71 to 80 of about 533,212 (256)

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

DNA markers associated with general and specific cognitive abilities

, 1996
Multivariate quantitative genetic research suggests a hierarchical model of cognitive abilities where genetic effects are largely general, cutting across most cognitive abilities. Some genetic effects, however, are specific to certain cognitive abilities.
Camilla Benbow, Plomin, Robert, McClearn, Gerald E., Smith, Deborah L., Chorney, Michael J., Peter McGuffin, Thompson, Lee A., Petrill, Stephen A., David Lubinski, Douglas K. Detterman, Owen, Michael John, Karen Chorney, Michael J. Chorney, Joanna Daniels, Robert Plomin, Chorney, Karen, Vignetti, Sylvia, McGuffin, Peter, Sylvia Vignetti, Michael J. Owen, Lee A. Thompson, Detterman, Douglas K., Daniels, Joanna, Gerald E. McClearn, Benbow, Camilla, Lubinski, David, Owen, Michael J., Stephen A. Petrill, Deborah L. Smith   +28 more
core   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

The dyslexia candidate locus on 2p12 is associated with general cognitive ability and white matter structure

, 2012
Independent studies have shown that candidate genes for dyslexia and specific language impairment (SLI) impact upon reading/language-specific traits in the general population.
Newbury, Dianne F, Dianne F Newbury, Dianne F. Newbury, Morris, Andrew P., Pennell, CE, Morris, Andrew P, Monaco, Anthony P, Anthony P. Monaco, Susan Ring, Ring, Susan, Whitehouse, Andrew J.O., Scerri, TS, Juha Kere, Ring Susan, Joel B Talcott, Fahimeh Darki, Hans Matsson, Pennell, Craig E, Whitehouse Andrew J. O., Morris Andrew P., Talcott, JB, Talcott Joel B., Torkel Klingberg, Kere Juha, Kere, Juha, Whitehouse, Andrew J O, Darki, Fahimeh, Monaco, AP, Stein, J, Ring, S, Myriam Peyrard, Joel B. Talcott, Silvia Paracchini, Craig E. Pennell, Qi W Ang, Thomas S. Scerri, Anthony P Monaco, Matsson Hans, Thomas S Scerri, Newbury Dianne F., Stein, John, Andrew P Morris, Ang Qi W., Ang, QW, Monaco, Anthony P., Paracchini, Silvia, Peyrard-Janvid, M, Myriam Peyrard-Janvid, Pennell Craig E., Klingberg, Torkel, John Stein, Ang, Qi W., Kere, J, Scerri Thomas S., Scerri, Thomas S, Pennell, Craig E., Talcott, Joel B., Matsson, Hans, Whitehouse, AJ, Craig E Pennell, Talcott, Joel B, Klingberg Torkel, Morris, Andrew, Peyrard-Janvid, Myriam, Whitehouse, Andrew J. O., Talcott, Joel, Monaco Anthony P., Ang, Qi W, Klingberg, T, Darki Fahimeh, Peyrard-Janvid Myriam, Paracchini, S, Morris, AP, Andrew P. Morris, Qi W. Ang, Stein John, Andrew J. O. Whitehouse, Matsson, H, Andrew J O Whitehouse, Newbury, Dianne F., Darki, F, Newbury, DF, Paracchini Silvia, Thomas S. Scerri, Scerri, Thomas S.   +84 more
core   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Developing individuals for developing learning based systems

, 2005
This thesis was submitted for the degree of Doctor of Philosophy and awarded by Brunel University.This research is concerned with investigating the externalisation, sharing and making tangible of tacit knowledge in the context of organisational learning (
Selamat, Mohamad
core  

Subject-specific abilities – Formulating goals in geography in school

, 2020
This article analyzes and discusses the construction of the Swedish syllabus in geography for compulsory school in relation to how knowledge is perceived in the curriculum.
Örbring, David
core  

A Reaching Test Reveals Weak Hand Preference in Specific Language Impairment and Developmental Co-ordination Disorder

, 1998
A reaching test for quantifying hand preference (QHP task) was given to 7- to 11-year-old children with specific language impairment (SLI) or developmental coordination disorder (DCD).
Bishop, Dorothy V., Hill, Elisabeth L.
core   +1 more source

Learning a new geometric concept: The role of working memory and of domain-specific abilities. [PDF]

Br J Educ Psychol, 2021
Rivella C, Cornoldi C, Caviola S, Giofrè D.   +3 more
europepmc   +1 more source