Results 101 to 110 of about 13,367,485 (282)

Molecular Glue Degraders Enhance CAPRIN1‐Dependent Lysosomal Degradation of APP and Reduce Amyloid β in Alzheimer's Disease

Advanced Science, EarlyView.
A new class of lysosome‐directed molecular glue degraders selectively enhance CAPRIN1–APP interactions, driving APP degradation and reducing amyloid‐β production in human neurons and Alzheimer's disease mouse models. This CAPRIN1‐dependent targeted protein degradation strategy reveals a previously unrecognized therapeutic approach for disrupting the ...
Sunghan Jung, Xu Wang, Bin Liu, Raktim Roy, Nancy Jaiswal, Ratan K. Rai, Yuichiro Takagi, Cen Gao, Lifan Zeng, Ho‐Yin Lo, Reagan K. Wohlford, Ryan K. Higgins, Bruce T. Lamb, Anantha Shekhar, Anita C. Bellail, Chunhai Hao   +15 more
wiley   +1 more source

Analysis of the Effect of Frequency Variation on SAR Test Results for Mobile Devices

Jurnal Sisfokom
The rapid advancement of telecommunications technology led to an expansion of frequency spectrum usage, which raised significant concerns regarding human radiation safety.
Naila Widhyadari, Endah Setyowati
doaj   +1 more source

A Dual‐Membrane Biomimetic Nanoplatform Enables Triple‐Modal Therapy Against SARS‐CoV‐2 Through Viral Decoy, Inflammation Neutralizing, and Intracellular RNAi

Advanced Science, EarlyView.
[A&T]MLN is a triple‐modal nanoplatform with siRNA‐loaded LN coated with hybrid ACE2/macrophage membrane. It blocks viral entry, neutralizes IL‐6/IL‐1β/TNF‐α, and delivers siRNA to suppress viral replication. In a murine lung injury model, it attenuates inflammation, offering a multi‐pronged strategy against SARS‐CoV‐2 variants and hyperinflammation ...
Hui Li, Bohan Zhang, Chao Shang, Yi Li, Te Zhao, Shengya Liu, Dan Liu, Junwei Che, Cuiling Zhang, Pinghui Wu, Wenjie Yang, Junjie Ding, Yuhua Ran, Yanan Zhai, Haihua Xiao, Jing Gao, Xiao Li, Chunsheng Gao, Lin Li, Zhiping Li   +19 more
wiley   +1 more source

Intelligent Programmable Membrane Nanosponge for Early Virus Blocking

Advanced Science, EarlyView.
A smart programmable nanosponge (ACNPs) displays high‐density viral receptors on its membrane and encapsulates fusion inhibitors to capture virions at the infection source through competitive binding and blocks their entry through protease inhibition for ultra‐early cascade interception. This modular, mucus‐penetrating platform shifts antiviral defence
Ze Chen, Zhuojun He, Huimin Guo, Min Shi, Ruijing Liang, Lanlan Liu, Yeneng Dai, Qi Zhao, Ke Liu, Yang Zhou, Yang Zhang, Jian Ren, Bin Ju, Quan Fang, Zhaozhen Li, Pengfei Zhao, Mingbin Zheng, Lintao Cai   +17 more
wiley   +1 more source

Solution‐Processed Multi‐Junction Optoelectronic Synapses for Mode‐Switchable SWIR Neuromorphic Vision Sensing

Advanced Science, EarlyView.
A novel bias‐programmable shortwave infrared (SWIR) vision sensor is developed using multi‐junction colloidal quantum dots (QDs). Under varying applied voltage, the back‐to‐back rectifying junctions effectively tune trapping centers to switch the device between high‐speed photodetector and persistent synapse modes.
Zhuoyang He, Dae Yang Oh, Yi Ji, Yanyan Li, Chengwei Shan, Soong Ju Oh, Tianshuo Zhao   +6 more
wiley   +1 more source

Self‐Assembling Peptide‐Adjuvant Conjugate (SaPAC) Platform for Precision Cancer Immunotherapy

Advanced Science, EarlyView.
A self‐assembling peptide–adjuvant conjugate links neoantigens to TLR7 agonism, forming cationic nanoparticles that enhance lymph‐node retention, dendritic‐cell activation, and antitumor T‐cell immunity. This chemically defined platform shows how synchronized antigen and innate stimulation can be adapted across melanoma, bladder cancer, and triple ...
Yang‐Fan Wu, Jing‐Chu Hu, Ye‐Fan Hu, Wen‐Jun Li, Li Rong, Ren‐Hao Li, Yuan Yao, Lehan Hu, Xiao‐Lei Wang, Bao‐Zhong Zhang, Yicheng Lu, Shing‐Fung Chow, Canhui Su, Thomas Yau, Clive Yik‐Sham Chung, Jian‐Dong Huang   +15 more
wiley   +1 more source

Analysis of SAR mitigation implementing millimeter wave antenna with FSS-based absorber for 5 G application

e-Prime: Advances in Electrical Engineering, Electronics and Energy
In this article, an FSS-based absorber has been developed and utilized to mitigate the specific absorption rate of a millimeter-wave antenna loaded with an inter-digital capacitor (IDC) for 5 G applications.
Nada N. Tawfeeq, Adheed H. Sallomi
doaj   +1 more source

Deciphering Structure‐Bubble‐Mass Transfer Relationships in Water Electrolysis Through Electrode Morphology Regulation

Advanced Science, EarlyView.
Electrode morphology is shown to govern oxygen‐bubble dynamics and interfacial mass transfer during water electrolysis. Positive‐curvature nanoneedles promote rapid release of small bubbles, sustain electrolyte renewal, and minimize mass‐transport losses, whereas flat and concave architectures increasingly retain bubbles.
Zhiqing Tang, Ziyun Zhang, Huicun Gu, Baoxin Wu, Kejun Yan, Jiahui Luo, Yuting Jiang, Cailin Xiao, Yu Xu, Lin Zeng   +9 more
wiley   +1 more source

Investigation of a Wearable Textile Monopole Antenna on Specific Absorption Rate at 2.45 GHz

, 2012
This paper discusses the investigation of a wearable textile monopole antenna on specific absorption rate (SAR) for bodycentric wireless communication applications at 2.45 GHz.
Norshafinash Saudin, Fareq Malek, Nur A. M. Affendi, Hasliza A. Rahim, Ahmad Sahadah, Azuwa Ali, Latifah Mohamed, Ismahayati Adam, Nur B. M. Hashim   +8 more
core   +1 more source

Lyssavirus Nucleoprotein Induces GPAT4‐Mediated CYB5R1 Depalmitoylation to Suppress Ferroptosis and Promote Viral Replication

Advanced Science, EarlyView.
Lipid metabolism plays a vital role in viral infections. Here, we reveal that the lyssavirus N protein regulates GPAT4 to induce lipid droplet biogenesis, restricting CYB5R1 palmitoylation and reducing ferroptosis susceptibility to ultimately promote viral replication.
Jianqing Zhao, Chuan Liang, Pingping Chen, Meixin Sun, Zhen F. Fu, Ling Zhao, Ming Zhou   +6 more
wiley   +1 more source