Results 231 to 240 of about 29,229,093 (355)

Design of Chitosan-Coated, Quercetin-Loaded PLGA Nanoparticles for Enhanced PSMA-Specific Activity on LnCap Prostate Cancer Cells. [PDF]

Biomedicines, 2023
Essa D, Kondiah PPD, Kumar P, Choonara YE.   +3 more
europepmc   +1 more source

Detection of specific polymerase chain reaction product by utilizing the 5'----3' exonuclease activity of Thermus aquaticus DNA polymerase.

Proceedings of the National Academy of Sciences of the United States of America, 1991
Pamela M. Holland, R. Abramson, R. Watson, D. Gelfand   +3 more
semanticscholar   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Antimalarial compounds exhibit variant- and cell-type-specific activity against SARS-CoV-2 isolated in Panama. [PDF]

Front Pharmacol
Quijada M, Castillo-Bultron M, Díaz Y, Pitti Y, Franco D, De La Guardia C, Campos D, Cornejo E, Núñez M, Mendoza L, López-Vergès S, Magallon-Tejada AH, Obaldia N.   +12 more
europepmc   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Anterior hypothalamic nucleus drives distinct defensive responses through cell-type-specific activity. [PDF]

iScience
Hong CY, Din JS, Chang H, Bang JY, Kim JC.   +4 more
europepmc   +1 more source

Controlling the toxicity of biomass-derived difunctional molecules as potential pharmaceutical ingredients for specific activity toward microorganisms and mammalian cells. [PDF]

Green Chem, 2023
Chang H, Chang DH, Stamoulis AG, Huber GW, Lynn DM, Palecek SP, Dumesic JA.   +6 more
europepmc   +1 more source

Cell-Type-Specific Activity in Prefrontal Cortex during Goal-Directed Behavior.

Neuron, 2015
L. Pinto, Y. Dan
semanticscholar   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

RLIM-specific activity reporters define variant pathogenicity in Tonne-Kalscheuer syndrome. [PDF]

HGG Adv
Bandi V, Rennie M, Koch I, Gill P, Pacheco OD, Berg AD, Cui H, Ward DI, Bustos F.   +8 more
europepmc   +1 more source