Results 31 to 40 of about 13,995,485 (256)

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Energy Efficiency Investments in Industry with Uncertain Demand Rate: Effects on the Specific Energy Consumption

Energies, 2019
The term “energy efficiency” covers a wide scope and it is affected by a lack of clarity. To overcome this issue, quantitative measures should be defined and evaluated for each unit of product or process considered.
Beatrice Marchi, Simone Zanoni, Ivan Ferretti   +2 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Energy Consumption Assessment of Percussive-Rotary Drilling in Hard Rock Massifs Based on Specific Fracture Energy [PDF]

E3S Web of Conferences
Percussive-rotary drilling is widely used for excavation in hard rock massifs, yet it suffers from high energy consumption and low efficiency. This study presents a comprehensive assessment of energy consumption in percussive-rotary drilling based on ...
Boranbay Ratov, Pashchenko Oleksandr, Rastsvietaiev Valerii, Haidai Oleksandr, Satybaldiyeva Dinara, Tabylganov Maksat   +5 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Applying Energy Efficiency Indicators in the Industrial Sector - Case Study in the Furniture Industry Focused on Electricity Consumption [PDF]

Brazilian Archives of Biology and Technology
Energy efficiency in the industrial sector aims to produce goods with lower energy consumption, using efficient practices and technologies throughout the production process, bringing economic, environmental, and social benefits.
Amanda Melo, Fernanda Perazzolo Disconzi
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

ANALISYS OF THE EFFICENCY OF THE SOURCES OF ELECTRIC AND THERMAL ENERGY IN VIEW OF SPECIFIC FUEL CONSUMPTION

Problems of the Regional Energetics, 2012
Methodological approach to the evaluation of specific energy consumption of the primary fuel for electricity and heat for the various types of power plants is designed. Method of reduction electrical energy to a thermal unit is offered.
Postolaty V.M., Bicova E.V.
doaj  

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Optimisation decision of machining process parameters considering milling energy consumption and specific cutting energy

Alexandria Engineering Journal
To address the challenges of high energy consumption and specific cutting energy in CNC milling operations, this study proposes a predictive–optimization integrated framework for multi-objective process parameter optimization.
Yang Xie, Shulong Mei, Chaoyong Zhang
doaj   +1 more source