Results 51 to 60 of about 516,930 (293)
Emerging role of ARHGAP29 in melanoma cell phenotype switching
Molecular Oncology, EarlyView.This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster +3 more
wiley +1 more source
Aerospace, 2023 A three-dimensional upwind conservation element and solution element method (CESE) in cylindrical coordinates is first developed to effectively solve the unsteady reactive Euler equations governing a hydrogen–air rotating detonation engine (RDE) with ...
Lisong Shi +5 more
doaj +1 more source
Screening for lung cancer: A systematic review of overdiagnosis and its implications
Molecular Oncology, EarlyView.Low‐dose computed tomography (CT) screening for lung cancer may increase overdiagnosis compared to no screening, though the risk is likely low versus chest X‐ray. Our review of 8 trials (84 660 participants) shows added costs. Further research with strict adherence to modern nodule management strategies may help determine the extent to which ...
Fiorella Karina Fernández‐Sáenz +12 more
wiley +1 more source
Control of Myelination by Specific Patterns of Neural Impulses [PDF]
The Journal of Neuroscience, 1998 A cell culture preparation equipped with stimulating electrodes was used to investigate whether action potential activity can influence myelination of mouse dorsal root ganglia axons by Schwann cells. Myelination was reduced to one-third of normal by low-frequency impulse activity (0.1 Hz), but higher-frequency stimulation (1 Hz) had no effect.
B, Stevens, S, Tanner, R D, Fields
openaire +2 more sources
Molecular Oncology, EarlyView.Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece +18 more
wiley +1 more source
Optimization of the Characteristics of High-Energy Materials
MATEC Web of Conferences, 2015 In work explored effect of mixed metallic fuel on the thermodynamic and ballistic characteristics of High-Energy Materials (HEMs). Efficiency of mixed metallic fuel estimated in relation to the characteristics of HEMs, containing conventional metallic ...
Kuznetsova Viktoriya, Savelieva Lilia
doaj +1 more source
Examining Metal Additives in a Marine Hybrid-Propellant, Water-Breathing Ramjet
Journal of Marine Science and Engineering, 2022 This research focuses on theoretically and experimentally evaluating the performance of a metallized hybrid-propellant, water-breathing ramjet. The aluminum and/or magnesium particles added to a polymeric (polyester) fuel grain are hydro-reactive, using ...
Nachum E. Eisen, Alon Gany
doaj +1 more source
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Aerospace, 2020 Electric solid propellants are advanced solid chemical rocket propellants that can be controlled (ignited, throttled and extinguished) through the application and removal of an electric current.
Matthew S. Glascock +2 more
doaj +1 more source
Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Molecular Oncology, EarlyView.Changes in passenger mutation load and predicted immunotherapy response after chemotherapy treatment. Tumor cells rich with passenger mutations have increased sensitivity to chemotherapy. Correlation of passenger mutations with neoantigen load suggests highly mutated clones promote a more effective response to immunotherapy, and therefore, first‐line ...
Marium T. Siddiqui +6 more
wiley +1 more source