Results 101 to 110 of about 2,290,362 (336)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Properties of bio-based gum Arabic/clay aerogels [PDF]

, 2016
Lightweight bio-based aerogels from sustainable gum Arabic (GA) and sodium montmorillonite (Na+-MMT) clay were prepared by means of a simple freeze-drying process. GA/clay aerogels showed high porosity (87.9%–94.9%) of mainly open type and the mechanical
Abt, Tobias Martin, Sánchez Soto, Miguel, Wang, Liang   +2 more
core   +2 more sources

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Experimental Study on Mechanical Specific Energy Optimization in Axial–Torsional Coupled Impact Drilling

Applied Sciences
Axial–torsional coupled impact drilling (ATCID) technology represents a promising solution for overcoming the drilling challenges posed by conglomerate formations, which are characterized by strong heterogeneity, high abrasiveness, and poor drillability.
Chuanming Xi, Desheng Wu, Chuanzhen Zang, Shen Wang, Yong Guo, Zongjie Mu, Zhehua Yang   +6 more
doaj   +1 more source

Architecture-independent power bound for vibration energy harvesters [PDF]

, 2013
The maximum output power of energy harvesters driven by harmonic vibrations is well known for a range of specific harvester architectures. An architecture-independent bound based on the mechanical input-power also exists and gives a strict limit on ...
Halvorsen, E, Le, CP, Mitcheson, PD, Yeatman, EM   +3 more
core   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Probing the interaction forces of prostate cancer cells with collagen I and bone marrow derived stem cells on the single cell level. [PDF]

, 2013
Adhesion of metastasizing prostate carcinoma cells was quantified for two carcinoma model cell lines LNCaP (lymph node-specific) and PC3 (bone marrow-specific).
Benoit, Martin, Clausen-Schaumann, Hauke, Docheva, Denitsa, Opfer, Jan, Padula, Daniela, Popov, Cvetan, Sariisik, Ediz, Schieker, Matthias   +7 more
core   +3 more sources

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

Molecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir, Lukasz Arcimowicz, Lucia Martinkova, Vaclav Hrabal, Filip Zavadil Kokas, Tomas Henek, Martina Kucerikova, Ondrej Bonczek, Pavlina Zatloukalova, Lenka Hernychova, Philip J. Coates, Borivoj Vojtesek, David P. Lane   +12 more
wiley   +1 more source

A Study of Static and Dynamic Mechanical Behavior of the Substrate in Ultrasonic Consolidation [PDF]

, 2006
A new 2-D FEM model is developed for a fundamental study of the time dependent mechanical behavior of the substrate in ultrasonic consolidation. The simulation shows that for a given vibration condition, the amplitude of contact friction stress and ...
Li, Leijun, Zhang, Chunbo
core   +1 more source