Results 101 to 110 of about 1,504,335 (301)

Correlation Research of TBM Tunnel Rock Mechanical Characteristics, Chiseling Specific Energy, and Abrasion Performance: Case Study of Jiaozhou Bay Subsea Tunnel in Qingdao

Geofluids, 2020
This paper takes Qingdao Jiaozhou Bay subsea tunnel project as the research object to study the relationship among rock mechanical parameters and chiseling specific energy and abrasion performance.
Yawei Wang, You Zhang, Guang Wu
doaj   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

Multi-Instantons and Exact Results II: Specific Cases, Higher-Order Effects, and Numerical Calculations

, 2004
In this second part of the treatment of instantons in quantum mechanics, the focus is on specific calculations related to a number of quantum mechanical potentials with degenerate minima.
Andrianov, Bailey, Brézin, Brézin, Buslaev, Damburg, Herbst, Itzykson, Jean Zinn-Justin, Jentschura, Jentschura, Jentschura, Lipatov, Lipatov, Lipatov, Press, Richardson, Seznec, Shifman, Ulrich D. Jentschura, Wichmann, Wolfram, Zinn-Justin, Zinn-Justin   +23 more
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Quantum versus Classical Dynamics in a driven barrier: the role of kinematic effects

, 2012
We study the dynamics of the classical and quantum mechanical scattering of a wave packet from an oscillating barrier. Our main focus is on the dependence of the transmission coefficient on the initial energy of the wave packet for a wide range of ...
E. Katifori, E. Mavrommatis, F. K. Diakonos, K. Husimi, P. K. Papachristou, S. E. Koonin, T. Dittrich, V. Constantoudis   +7 more
core   +1 more source

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source

Mechanical properties and deformation mechanism of laser melting octagonal double pyramid and Kelvin hybrid lattice structure

Journal of Aeronautical Materials
Due to their excellent mechanical properties，dot matrix structures show a broad application prospect for spacecraft lightweight structures and cushioning energy absorbing devices.
YU Jingui, ZHU Yao, ZHANG Qiaoxin
doaj   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Multi-Instantons and Exact Results I: Conjectures, WKB Expansions, and Instanton Interactions

, 2004
We consider specific quantum mechanical model problems for which perturbation theory fails to explain physical properties like the eigenvalue spectrum even qualitatively, even if the asymptotic perturbation series is augmented by resummation ...
Andrianov, Bogomolny, Brézin, Buslaev, Damburg, Davydov, Delabaere, Delabaere, Itzykson, Jean Zinn-Justin, Jentschura, Jentschura, Rosenbrock, Seznec, Shifman, Ulrich D. Jentschura, Voros, Zinn-Justin, Zinn-Justin, Zinn-Justin, Zinn-Justin, Zinn-Justin, Zinn-Justin   +22 more
core   +1 more source