Results 71 to 80 of about 623 (200)

The Hidden Burden of Hemifacial Spasm: A Systematic Review of Non‐Motor Symptoms

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Hemifacial spasm (HFS) is a chronic neurological disorder characterized by involuntary contractions of facial muscles. Traditionally regarded as a motor condition, HFS encompasses a spectrum of non‐motor symptoms that are often overlooked but significantly affect patients’ quality of life.
Miriam Carvalho Soares, Jacy Bezerra Parmera, Pedro Augusto Sampaio Rocha‐Filho   +2 more
wiley   +1 more source

Neuroimaging in specific phobia disorder: a systematic review of the literature Neuroimagem do transtorno de fobia específica: uma revisão sistemática da literatura

Brazilian Journal of Psychiatry, 2012
OBJECTIVE: Specific phobia (SP) is characterized by irrational fear associated with avoidance of specific stimuli. In recent years, neuroimaging techniques have been used in an attempt to better understand the neurobiology of anxiety disorders.
Ila M.P Linares, Clarissa Trzesniak, Marcos Hortes N Chagas, Jaime E. C Hallak, Antonio E Nardi, José Alexandre S Crippa   +5 more
doaj   +1 more source

A Review of Advances in Composite Materials, Structural Optimization, and Machine Learning for Wind Turbine Blades: Challenges and Future Perspectives

Polymer Composites, EarlyView.
Overview of the holistic engineering lifecycle and core research pillars for wind turbine blades. ABSTRACT This paper reviews recent advancements across the lifecycle of wind turbine blades, focusing on three interconnected areas: advanced composites, structural optimization, and machine learning (ML) diagnostics. In materials, we highlight progress in
Kemal Hasirci, Denizhan Yavas, Alaeddin Burak Irez   +2 more
wiley   +1 more source

Structural and Stability Analysis of de Novo Designed Proteins Incorporating a Plant Self‐Incompatibility Motif

Proteins: Structure, Function, and Bioinformatics, EarlyView.
ABSTRACT Artificial protein design enables the creation of stable scaffolds beyond those evolved in nature. Incorporation of native functional motifs into de novo scaffolds provides a promising strategy to mimic natural interactions while altering structural frameworks.
Hakuto Miyoshi, Koya Sakuma, Yoshitaka Moriwaki, Naoki Aoyama, Toma Kashima, Tohru Terada, Akimasa Miyanaga, Shinya Fushinobu   +7 more
wiley   +1 more source

Who Knows, Cares and Acts for Sustainability in Times of Uncertainty? Demographic Differences in Perceived Knowledge, Concerns, and Pro‐Environmental Behaviors

Sustainable Development, EarlyView.
ABSTRACT In 2026, some years after the Covid‐19 pandemic and the related economic crisis, the global landscape remains profoundly unsettled. Geopolitical conflicts, such as the war between Russia and Ukraine and the Middle East conflicts, continue to drive instability, reshaping global priorities and challenges.
Rosa Maria Dangelico, Serena Filippelli, Luca Fraccascia, Andrea Viggiani   +3 more
wiley   +1 more source

Endocytosis‐independent cytosolic entry of messenger RNA via fluorous bilayer zippering attenuating Toll‐like receptor signaling and enables ischemic tissue salvage

Smart Molecules, EarlyView.
The present study establishes a paradigm shift in synthetic mRNA delivery through the convergence of three orthogonal chemistries—perfluoro‐acylation, bio‐orthogonal click cross‐linking, and disulfide reduction—within a single, modular polymer architecture. Abstract A fundamental constraint of conventional messenger RNA (mRNA) delivery systems is their
Yue Wang, Haitao Xie, Guoqing Xiang, Yanhua Li, Changgui Tong, Hongyan Cui, Qixian Chen, Haidong Li, Yan Zhao   +8 more
wiley   +1 more source

Recent progress on the development of hydrogel‐based microneedles for transdermal drug delivery

VIEW, EarlyView.
This study provides a comprehensive and up‐to‐date analysis of recent progress in HMN technology, covering fundamental transdermal delivery mechanisms and design principles, biomaterials used in HMN fabrication, drug loading and release strategies, and emerging therapeutic applications.
Mohammad Muhtasim Ittisaf, Salman Farsi Taharat, Md. Sadek Miah, Hasan Tasnim Salehin, M. Azam Ali, Shoeb Ahmed   +5 more
wiley   +1 more source

Cardiometabolic Treatment Gap in Routine Psychiatric Care: A Cross‐Sectional Study of 1553 Patients

Acta Psychiatrica Scandinavica, EarlyView.
ABSTRACT Background People with severe mental illness (SMI) have elevated cardiometabolic morbidity and mortality, with similar concerns increasingly reported in other psychiatric conditions including anxiety disorders and ADHD. Somatic conditions are often underdiagnosed and pharmacologically undermanaged in this population.
Vincent Achour, Melanie Faugere, Laurent Boyer, Christophe Lançon, Theo Korchia   +4 more
wiley   +1 more source

Psilocybin in alcohol use disorder and comorbid depressive symptoms: Results from a feasibility randomized clinical trial

Addiction, EarlyView.
Abstract Background and Aims Psilocybin has emerged as a potential treatment for alcohol use disorder (AUD), but early efficacy data are inconsistent. Depression following alcohol detoxification significantly increases the risk of relapse. This pilot study aimed to evaluate the feasibility, acceptability, and preliminary efficacy of psilocybin‐assisted
Amandine Luquiens, Dahbia Belahda, Carine Graux, Noe Igounenc, Chris Serrand, Paul Rochefort, Thibault Mura, Felix Sergent   +7 more
wiley   +1 more source

Virtual Reality Exposure Therapy for Treating Fear of Contamination Disorders: A Systematic Review of Healthy and Clinical Populations

Brain Sciences
Virtual Reality Exposure Therapy (VRET), particularly immersive Virtual Reality Exposure Therapy (iVRET), has gained attraction as an innovative approach in exposure therapy (ET), notably for some anxiety disorders with a fear of contamination component,
Francesca Ferraioli, Laura Culicetto, Luca Cecchetti, Alessandra Falzone, Francesco Tomaiuolo, Angelo Quartarone, Carmelo Mario Vicario   +6 more
doaj   +1 more source