Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Iron-Doped Molybdenum Sulfide Nanoflowers on Graphene for High-Performance Supercapacitors
MoleculesSupercapacitors (SCs) are widely acknowledged for their high-power density as energy storage devices; designing electrode materials with both high efficiency and exceptional energy density remains a significant challenge.
Xuyang Li +6 more
doaj +1 more source
Effect of Temperature on Deformation and Fatigue Behaviour of A356-T7 Cast Aluminium Alloys Used in High Specific Power IC Engine Cylinder Heads. [PDF]
Materials (Basel), 2020 Natesan E +3 more
europepmc +1 more source
Siting Issues for Solar Thermal Power Plants with Small Community Applications [PDF]
Technologies for solar thermal plants are being developed to provide energy alternatives for the future. Implementation of these plants requires consideration of siting issues as well as power system technology.
Holbeck, J. J., Ireland, S. J.
core +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Effects of Dwell Time on the Deformation and Fatigue Behaviour of A356-T7 Cast Aluminium Alloys Used in High Specific Power IC Engine Cylinder Heads. [PDF]
Materials (Basel), 2020 Natesan E +4 more
europepmc +1 more source
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Auction Basics for Wholesale Power Markets: Objectives and Pricing Rules [PDF]
Power systems have distinctive features that greatly complicate the development of auction designs. This study reviews the theory and practice of auction design as it relates specifically to U.S.
Tesfatsion, Leigh
core