Results 91 to 100 of about 167,683,516 (269)
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer
Molecular Oncology, EarlyView.Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim +7 more
wiley +1 more source
Sustainable FuturesReducing packaging-related environmental burden has become a key priority in the agri-food sector, especially in light of regulatory pressures and sustainability goals.
G. Bartolotti +6 more
doaj +1 more source
Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy
Molecular Oncology, EarlyView.We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen +19 more
wiley +1 more source
Analysis of the breakage rate function for selected process parameters in quartzite milling [PDF]
, 2012 The paper presents the results of studies on quartzite milling in a ball mill. The milling was conducted in a batch system, for diversified compositions of balls.
Olejnik, T. P.
core
Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
The effect of ball size on breakage rate parameter in a pilot scale ball mill
, 2009 The objective of this study is to investigate the effect of ball size on grinding kinetics in a pilot scale ball mill. Six different ball media gradings were tested.
ERGÜN, ŞEVKET LEVENT, Erdem, A. Seyfi
core +1 more source
Particle breakage mechanics in milling operation [PDF]
, 2017 Milling is a common unit operation in industry for the purpose of intentional size reduction. Considerable amount of energy is consumed during a grinding process and much of the energy is dissipated as heat and sound, which often makes grinding into an ...
Wang, Li Ge
core +2 more sources
HeliyonCasing wear is a persistent issue in oil and gas drilling facilities that call for innovative more wear-resistant materials to mitigate casing failures.
Y. Fouad +8 more
doaj +1 more source