Results 141 to 150 of about 3,330,118 (346)
A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner
Molecular Oncology, EarlyView.We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp +13 more
wiley +1 more source
Finger-specific effects of age on tapping speed and motor fatigability
Frontiers in Human NeuroscienceIntroductionIncreased motor fatigability is a symptom of many neuromuscular and neurodegenerative disorders. However, it is difficult to pinpoint pathological motor fatigability, since the phenomena has not yet been fully characterized in the healthy ...
Caroline Heimhofer +8 more
doaj +1 more source
Molecular Oncology, EarlyView.Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley +1 more source
Effects of Specific RAMP Protocol Phase on Change of Direction Speed of Police Students
Journal of Functional Morphology and KinesiologyBackground: This study assessed the effects of two distinct RAMP (Raise, Activate, Mobilize, Potentiate) protocols, mobility-focused and reactiveness-focused, on change of direction speed in police students (i.e., tactical athletes).
Filip Kukić +7 more
doaj +1 more source
Molecular Oncology, EarlyView.TRIM24 and TRIM28 are androgen receptor (AR) coregulators which exhibit increased expression with cancer progression. Both TRIM24 and TRIM28 combine to influence the response of castrate‐resistant prostate cancer (CRPC) cells to AR inhibitors by mediating AR signalling, regulation of MYC and upregulating VEGF to promote angiogenesis. Castrate‐resistant
Damien A. Leach +8 more
wiley +1 more source
THE EFFECTS OF SPECIFIC TRAINING ON THE FORMS OF SPEED MANIFESTATION IN JUDO
Sport şi Societate, 2015 The purpose of the study was to investigate the influences specific speed training on the forms of its manifestation in judo. Methods: The subjects of the survey were two 10-student groups practicing judo at C.S.S. Gloria of Arad – a control group (C.Gr.:
Galea Ioan +2 more
doaj
EFFECT OF LONGITUDINAL SLOPE ANGLES, VIBRATION SPEEDS AND OUTLETS FOR THE PRODUCE IN GRADING, SEPARATOR OF WHEAT SEED BY USING SPECIFIC GRAVITY SEPARATOR LOCALLY MANUFACTURE [PDF]
, 2005 Yasen H. Al tahan
openalex +1 more source
EMT‐associated bias in the Parsortix® system observed with pancreatic cancer cell lines
Molecular Oncology, EarlyView.The Parsortix® system was tested for CTC enrichment using pancreatic cancer cell lines with different EMT phenotypes. Spike‐in experiments showed lower recovery of mesenchymal‐like cells. This was confirmed with an EMT‐inducible breast cancer cell line.
Nele Vandenbussche +8 more
wiley +1 more source