Results 151 to 160 of about 3,494,207 (343)

Finger-specific effects of age on tapping speed and motor fatigability

Frontiers in Human Neuroscience
IntroductionIncreased motor fatigability is a symptom of many neuromuscular and neurodegenerative disorders. However, it is difficult to pinpoint pathological motor fatigability, since the phenomena has not yet been fully characterized in the healthy ...
Caroline Heimhofer, Caroline Heimhofer, Amira Neumann, Ingrid Odermatt, Ingrid Odermatt, Marc Bächinger, Nicole Wenderoth, Nicole Wenderoth, Nicole Wenderoth   +8 more
doaj   +1 more source

Volute throat area and wall modelling influence on the numerical performances of a very low specific speed pump [PDF]

, 2021
Lilian Chabannes, David Štefan, Pavel Rudolf   +2 more
openalex   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Relating Electric Vehicle Charging to Speed Scaling with Job-Specific Speed Limits

Operations Research
With the adoption of electric vehicles emerges a need for coordinated charging strategies to cater to the increased and often synchronized energy demand without violating physical infrastructure limits. Common charging strategies repeatedly solve a corresponding offline problem. In “Relating Electric Vehicle Charging to Speed Scaling with Job-Specific
Leoni Winschermann, Antonios Antoniadis, Marco E. T. Gerards, Gerwin Hoogsteen, Johann Hurink   +4 more
openaire   +2 more sources

Abiotic stress and tissue-specific reference genes for quantitative reverse transcription PCR analysis in Korean native watermelons, Citrullus lanatus ‘Black-King’ and ‘Speed-Plus-Honey’ [PDF]

, 2018
Soo Jin Kim, Il Lae Jung, Hye‐Eun Lee, Ji-Hoon Lee   +3 more
openalex   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

THE EFFECTS OF SPECIFIC TRAINING ON THE FORMS OF SPEED MANIFESTATION IN JUDO

Sport şi Societate, 2015
The purpose of the study was to investigate the influences specific speed training on the forms of its manifestation in judo. Methods: The subjects of the survey were two 10-student groups practicing judo at C.S.S. Gloria of Arad – a control group (C.Gr.:
Galea Ioan, Ardelean Viorel Petru , Popa Lucia   +2 more
doaj  

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Influence of Different Performance Levels on Pacing Strategy During the Women's World Championship Marathon Race. [PDF]

Purpose To analyse pacing strategies displayed by athletes achieving differing levels of performance during an elite level marathon race. Methods Competitors in the 2009 IAAF Women’s Marathon Championship were split into Groups 1, 2, 3, and 4 ...
Renfree, Andrew, St Clair Gibson, Alan
core  

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source