Results 51 to 60 of about 532,868 (319)

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

Molecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source

A large‐scale retrospective study in metastatic breast cancer patients using circulating tumour DNA and machine learning to predict treatment outcome and progression‐free survival

Molecular Oncology, EarlyView.
There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes, Mario Ortega Duran, Solon Karapanagiotis, Alistair Martin, Meiling Gao, Riccardo Masina, Ramona Woitek, James Tanner, Fleur Tippin, Justine Kane, Jonathan Lay, Anja Brouwer, Stephen‐John Sammut, Suet‐Feung Chin, Davina Gale, Dana W. Y. Tsui, Sarah‐Jane Dawson, Nitzan Rosenfeld, Maurizio Callari, Oscar M. Rueda, Carlos Caldas   +20 more
wiley   +1 more source

Construction of CFC-programs by LTL-specification

Моделирование и анализ информационных систем, 2016
This article continues a cycle of papers, which describe an approach to construction and verification of discrete PLC-programs by an LTL-specification. The approach provides a possibility of PLC-program correctness analysis by the model checking method ...
D. A. Ryabukhin, E. V. Kuzmin, V. A. Sokolov   +2 more
doaj   +1 more source

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

Molecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam   +14 more
wiley   +1 more source

Architecture Diagrams: A Graphical Language for Architecture Style Specification [PDF]

Electronic Proceedings in Theoretical Computer Science, 2016
Architecture styles characterise families of architectures sharing common characteristics. We have recently proposed configuration logics for architecture style specification.
Anastasia Mavridou, Eduard Baranov, Simon Bliudze, Joseph Sifakis   +3 more
doaj   +1 more source

Automated Conditional Statements Checking for Complete Natural Language Requirements Specification

Applied Sciences, 2021
Defects such as the duality and the incompleteness in natural language software requirements specification have a significant impact on the success of software projects.
Chun Liu, Zhengyi Zhao, Lei Zhang, Zheng Li   +3 more
doaj   +1 more source

CML: the commonKADS conceptual modelling language [PDF]

, 1994
We present a structured language for the specification of knowledge models according to the CommonKADS methodology. This language is called CML (Conceptual Modelling Language) and provides both a structured textual notation and a diagrammatic notation ...
Akkermans, J.M., Akkermans, J.M., Anjewierden, Anjo Allert, Schreiber, G., van de Velde, W., Wielinga, B.J.   +5 more
core   +2 more sources

Circulating tumor DNA monitoring and blood tumor mutational burden in patients with metastatic solid tumors treated with atezolizumab

Molecular Oncology, EarlyView.
In patients treated with atezolizumab as a part of the MyPathway (NCT02091141) trial, pre‐treatment ctDNA tumor fraction at high levels was associated with poor outcomes (radiographic response, progression‐free survival, and overall survival) but better sensitivity for blood tumor mutational burden (bTMB).
Charles Swanton, Russell W. Madison, Candice Francheska B. Tambaoan, Funda Meric‐Bernstam, Christopher J. Sweeney, Razelle Kurzrock, Howard A. Burris III, David R. Spigel, Hanna Tukachinsky, Jason Hughes, Julia Malato, Bongin Yoo, Tania Szado, Cheryl Schwab, Lincoln W. Pasquina, Amaya Gasco, Katja Schulze, Claire F. Friedman   +17 more
wiley   +1 more source

LeGESD: A framework oriented to the specification and formal validation of concurrent and distributed systems based on a graphical language and its process algebra semantics

Revista Facultad de Ingeniería Universidad de Antioquia, 2012
The specification and formal verification of distributed systems is usually a complex task. It requires extensive knowledge of algorithm theory and modeling of distributed or concurrent systems.
Jorge Cortés Galicia, Felipe M. Menchaca García, Rolando Menchaca Méndez   +2 more
doaj   +1 more source

A specification language

, 1982
This paper gives an informal presentation of the language currently used at the Programming Research Group. Oxford University for documenting the specification and the design of computer systems. The language is an extension of conventional set theoretical notation.
openaire   +3 more sources