Results 221 to 230 of about 4,525,804 (339)

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

Molecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp, Wouter P. R. Verdurmen, Jonas V. Schaefer, Kari Kopra, Gabriela Nagy‐Davidescu, Elodie Richard, Marie‐Julie Nokin, Patrick Ernst, Rastislav Tamaskovic, Martin Schwill, Ralph Degen, Claudia Scholl, David Santamaria, Andreas Plückthun   +13 more
wiley   +1 more source

Independent confirmation of the immunophenotypic ELN Scoring System in patients with MDS and CMML. [PDF]

Hemasphere
Oelschlaegel U, Schadt J, Epp K, Wagenführ L, Ruhnke L, Kroschinsky F, Bornhäuser M, Sockel K, von Bonin M, Röhnert MA.   +9 more
europepmc   +1 more source

Does Gender Specificity in Constitutions Matter? [PDF]

, 2009
Lucas, Laura E.
core   +1 more source

Effects of Specific Antisera on the Growth of Bacterial Viruses (Bacteriophages) [PDF]

, 1945
M. Delbrück
openalex   +1 more source

Tissue-specific and species-specific esterases [PDF]

Biochemical Journal, 1961
P. F. Fottrell, James Paul
openaire   +3 more sources

Unraveling LINE‐1 retrotransposition in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
The novel RetroTest method allows the detection of L1 activation in clinical samples with low DNA input, providing global L1 activity and the identification of the L1 source element. We applied RetroTest to a real‐world cohort of HNSCC patients where we reported an early L1 activation, with more than 60% of T1 patients showing L1 activity.
Jenifer Brea‐Iglesias, Ana Oitabén, Sonia Zumalave, Bernardo Rodriguez‐Martin, María Gallardo‐Gómez, Martín Santamarina, Ana Pequeño‐Valtierra, Laura Juaneda‐Magdalena, Ramón García‐Escudero, José Luis López‐Cedrún, Máximo Fraga, José M. C. Tubio, Mónica Martínez‐Fernández   +12 more
wiley   +1 more source

Diagnostic accuracy of a commercial AI digital stethoscope for diagnosis of TB. [PDF]

IJTLD Open
Cox H, Rani Y, Nakiyingi L, Francia KA, Xie Y, Hoang C, Hapeela N, Romero GP, Nasinghe E, Van Hung N, Kim S, Penn-Nicholson A, Dorman SE, FEND-TB Consortium.   +13 more
europepmc   +1 more source

TYPE-SPECIFIC PROTECTION AND IMMUNITY FOLLOWING INTRANASAL INOCULATION OF MONKEYS WITH GROUP A HEMOLYTIC STREPTOCOCCI [PDF]

, 1946
Robert F. Watson, Sidney Rothbard, Homer F. Swift   +2 more
openalex   +1 more source

BMP antagonist CHRDL2 enhances the cancer stem‐cell phenotype and increases chemotherapy resistance in colorectal cancer

Molecular Oncology, EarlyView.
Overexpression of CHRDL2 in colon cancer cells makes them more stem‐like and resistant to chemo‐ and radiotherapy. CHRDL2‐high cells have upregulation of the WNT pathway, genes involved in the DNA damage response (DDR) pathway and epithelial‐to‐mesenchymal transition (EMT). This leads to quicker repair of damaged DNA and more cell migration.
Eloise Clarkson, Annabelle Lewis
wiley   +1 more source

The diagnostic performance of a noninvasive urine-based methylation biomarkers Vimentin/POU4F2 to detect bladder carcinoma. [PDF]

BMC Cancer
Zhang J, Cheng X, Huang C, Xu Y, He J, Xu H, Tai S, Wei Y.   +7 more
europepmc   +1 more source