Results 201 to 210 of about 797,061 (291)

ZBTB18 Dysfunction Promotes Neuropathic Pain via CHD4‐based Epigenetic Disinhibition of CLIC1 Channels in Sensory Neurons

Advanced Science, EarlyView.
In this study, we identify a novel functional role of ZBTB18 in regulating trigeminal‐mediated neuropathic pain. Nerve injury reduces ZBTB18 in trigeminal ganglion neurons, impairing CHD4/NuRD recruitment and de‐repressing Clic1. Elevated CLIC1 enhances chloride channel activity and neuronal hyperexcitability, thereby driving pain.
Shoupeng Wang, Zitong Huang, Yu Tao, Yunmei Zhang, Yufang Sun, Dongsheng Jiang, Weiwei Lu, Fuhai Ji, Gang Chen, Min Xu, Yuan Zhang, Jin Tao   +11 more
wiley   +1 more source

Left atrial functional recovery precedes volumetric reverse remodeling after TAVI by speckle tracking echocardiography. [PDF]

Sci Rep
Li G, Liu N, Sun W, Xu K, Wang B, Zhou W, Han Y.   +6 more
europepmc   +1 more source

In Vivo Direct Reprogramming: Current Progress and Future Prospects from Mechanisms to Therapeutic Application

Advanced Science, EarlyView.
This review examines the potential of in vivo direct reprogramming in regenerative medicine for functional tissue restoration, highlighting the role of tissue‐resident cues in generating functionally mature reprogrammed cells from lineage‐related cells. It contains a discussion on mechanisms, reprogramming factors, delivery approaches, and applications
Rishabh Deo Singh, Mauro Calvoli, Kyeong Kyu Kim   +2 more
wiley   +1 more source

Clinical study to evaluate the effect of different types of dyslipidemia on left ventricular function based on three-dimensional speckle tracking imaging. [PDF]

Int J Cardiol Cardiovasc Risk Prev
Chen X, Jiang Z, Sun P, He X, Tian Y, Lv Q.   +5 more
europepmc   +1 more source

Deep‐Learning‐Based Denoising for Improved Phase Precision in Electron Holography of Electromagnetic Fields in Nanoscale Materials

Advanced Science, EarlyView.
Low‐dose electron holography is limited by shot noise, which buries weak phase signals. HoloDenoiser, a physics‐informed network that works simultaneously in the spatial and frequency domains, locates and protects the holographic sideband while suppressing noise in the hologram.
Ye Luo, Luyang Wang, Zhiling Yu, Xiaowen Chen, Xiaoyu Wang, Ya‐Hui Jia, Thibaud Denneulin, Yu Han, Rafal E. Dunin‐Borkowski, Fengshan Zheng, Qi Liu   +10 more
wiley   +1 more source

Impact of mitral regurgitation on left atrial appendage functions: the efficacy of speckle tracking echocardiography. [PDF]

BMC Cardiovasc Disord
Yaman B, Başyiğit F, Turan N, Özbebek YE, Altuner TK, Tolunay H.   +5 more
europepmc   +1 more source

Electronics‐Free Visual Monitoring of Dry Eye Disease‐Related Tear Biomarkers Using Smart Scleral Lenses

Advanced Science, EarlyView.
An electronics‐free smart scleral lens passively monitors dry eye disease‐related tear biomarkers through colorimetric sensing of chloride, pH, and ocular surface temperature. Smartphone‐assisted image analysis enables quantitative interpretation, providing a simple, non‐invasive strategy for ocular health monitoring without integrated electronics ...
Ziheng Wang, Sang Mok Park, Dawn Meyer, Seul Ah Lee, Yumin Dai, Tianhao Yu, Taewoong Park, Feiyang Li, Jason Gerard Jedlicka, Tristan Michael Long, Oluwabunmi T. Oladele, Gillian C. Shaw, Shin Ae Park, Pete S. Kollbaum, Young L. Kim, Chi Hwan Lee   +15 more
wiley   +1 more source

Applications of speckle tracking echocardiography in paediatric and congenital heart disease: an expert consensus paper from AEPC Imaging Working Group. [PDF]

Eur Heart J Imaging Methods Pract
Cantinotti M, Ramcharan T, Dorobantu DM, McMahon C, Garrido AO, Brida M, Pasqualin G, Raimondi F, Bonnello B, Meyer-Szary J, Rotés AS, Miller O, Brun H, Bhat M, Doros G, Grotenhuis H, Olejnik P, Koestenberger M, Anagnostopoulou A, Koopman L, Khraiche D, Leskinen M, Voges I, Sunnegårdh J, Krupickova S, Velasco MN, Van De Bruaene A, Di Salvo G.   +27 more
europepmc   +1 more source

ACSL4‐Dependent Lysosomal Lipid Peroxidation Links WTAP‐Mediated m6A Modification to Intervertebral Disc Degeneration

Advanced Science, EarlyView.
IL‐1β upregulates the protein level of WTAP, which promotes the m6A modification of ACSL4 mRNA in an IGF2BP2‐dependent manner, thereby enhancing its stability. The increased ACSL4 drives lipid peroxidation, leading to lysosomal membrane permeabilization (LMP) and impaired mitophagy, which collectively accelerate intervertebral disc degeneration (IVDD).
Shu Jia, Xu Gao, Laimin Zhu, Haixia Song, Jing Wu, Shang Chen, Sheng Gao, Lu Zhang, Chunyang Meng   +8 more
wiley   +1 more source

The influence of accessory pathway localization on left ventricular mechanics in adult patients with Wolff-Parkinson-White syndrome: a speckle-tracking echocardiographic investigation. [PDF]

Quant Imaging Med Surg
Li M, Chen F, Yao J, Chen X, Wang X, Ge B, Xu F, Zhang P, Wang S.   +8 more
europepmc   +1 more source