Results 71 to 80 of about 133,909 (293)

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Analysis of Despeckling Filters Using Ratio Images and Divergence Measurement

Remote Sensing
This paper presents an analysis of different despeckling filters applied on both synthetically corrupted optical images and actual Synthetic Aperture Radar (SAR) images. Several authors use optical images as ground truth and then the images are corrupted
Luis Gómez, Ahmed Alejandro Cardona-Mesa, Rubén Darío Vásquez-Salazar, Carlos M. Travieso-González   +3 more
doaj   +1 more source

Laser-induced speckle scatter patterns in Bacillus colonies

Frontiers in Microbiology, 2014
Label-free bacterial colony phenotyping technology called BARDOT (BActerial Rapid Detection using Optical scattering Technology) provided successful classification of several different bacteria at the genus, species, and serovar level. Recent experiments
Huisung eKim, Atul K Singh, Arun K Bhunia, Euiwon eBae   +3 more
doaj   +1 more source

High-resolution and broadband all-fiber spectrometers

, 2014
The development of optical fibers has revolutionized telecommunications by enabling long-distance broad-band transmission with minimal loss. In turn, the ubiquity of high-quality low-cost fibers enabled a number of additional applications, including ...
Alam, Mansoor, Cao, Hui, Redding, Brandon, Seifert, Martin   +3 more
core   +1 more source

Functional Connectivity Linked to Cognitive Recovery After Minor Stroke

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Patients with minor stroke exhibit slowed processing speed and generalized alterations in functional connectivity involving frontoparietal cortex (FPC). The pattern of connectivity evolves over time. In this study, we examine the relationship of functional connectivity patterns to cognitive performance, to determine ...
Vrishab Commuri, Isabella Dallasta, Ciaran Stone, Sophia Girgenti, Neda Gould, Rafael H. Llinas, Jonathan Z. Simon, Elisabeth Breese Marsh   +7 more
wiley   +1 more source

Nanometric displacements measurement in piezoelectric polymers using bivariate empirical mode decomposition method in speckle patterns

Revista Elektrón, 2019
In this work we present an optical method for the direct determination of the piezoelectric coefficient of polymeric thin films. This is achieved through the measurement of nanometric mechanical displacements generated in the film when it is excited by ...
Pablo Etchepareborda, Francisco Veiras, Arturo Bianchetti, Alejandro Federico, Martin German Gonzalez   +4 more
doaj  

Speckle pattern formation in spatially limited optical systems

Semiconductor Physics, Quantum Electronics & Optoelectronics, 2016
The dependences of statistical parameters inherent to speckle patterns on the object roughness and aperture size have been investigated. The experimental results that confirm theoretical dependence quality within the limits of errors were obtained.
M.M. Kotov
doaj   +1 more source

Whole‐Body Pattern of Muscle Degeneration and Progression in Sarcoglycanopathies

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To characterize whole‐body intramuscular fat distribution pattern in patients with sarcoglycanopathies and explore correlations with disease severity, duration and age at onset. Methods Retrospective, cross‐sectional, multicentric study enrolling patients with variants in one of the four sarcoglycan genes who underwent whole‐body ...
Laura Costa‐Comellas, Mauro Monforte, Angel Sanchez‐Montañez, Penélope Romero‐Duque, Elena Pegoraro, Jordi Díaz‐Manera, Dmitry Vlodavets, Lorenzo Maggi, Marco Moscatelli, Adele D‘Amico, Montse Olivé, Jorge Alonso‐Pérez, Giacomo Comi, José Miguel Escudero‐Fernández, Gabriela S. Urcuyo, Anna Pichiecchio, Angela Berardinelli, Kristl G. Claeys, Claudio Bruno, Chiara Panicucci, Sara Bortolani, Eleonora Torchia, Enzo Ricci, Soledad Monges, Jorge A. Bevilacqua, Jorge Diaz‐Jara, Maggie C. Walter, Simone Thiele, Nicoline Løkken, John Vissing, Susana Quijano‐Roy, Robert Y. Carlier, Nicol C. Voermans, Chiara Marini‐Bettolo, Michela Guglieri, Volker Straub, Lea Leonardis, Francina Munell, David Gómez‐Andrés, Giorgio Tasca   +39 more
wiley   +1 more source

Speckle filtering of Synthetic Aperture Radar images using filters with object-size-adapted windows

International Journal of Digital Earth, 2018
Speckle degrades the radiometric quality of a Synthetic Aperture Radar (SAR) image. Previous methods for speckle reduction have used a fixed-size window for filtering the entire image.
Sahel Mahdavi, Bahram Salehi, Cecilia Moloney, Weimin Huang, Brian Brisco   +4 more
doaj   +1 more source