Results 61 to 70 of about 61,457 (342)
Molecular Oncology, EarlyView.HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto +13 more
wiley +1 more source
Length of Polarization-Correlation Based on Speckle Pattern for Optical Coherent Detection
IEEE Photonics JournalA length of polarization-correlation (LPC) based on speckle pattern of the non-uniform spatial polarization distribution is proposed and measured by using the classical measurement method of the Stokes polarization parameters for optical coherent ...
Longkun Zhang +3 more
doaj +1 more source
High-resolution and broadband all-fiber spectrometers
, 2014 The development of optical fibers has revolutionized telecommunications by enabling long-distance broad-band transmission with minimal loss. In turn, the ubiquity of high-quality low-cost fibers enabled a number of additional applications, including ...
Alam, Mansoor +3 more
core +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Instabilities of waves in nonlinear disordered media
, 2000 We develop a self-consistent theory of temporal fluctuations of a speckle pattern resulting from the multiple scattering of a coherent wave in a weakly nonlinear disordered medium.
A. A. Golubentsev +30 more
core +2 more sources
FEBS Open Bio, EarlyView.IqgC is a RasGAP from Dictyostelium discoideum. IqgC binds RasG via its RasGAP domain and deactivates it on macroendocytic cups, thereby suppressing the uptake of fluid and particles. IqgC has a positive effect on cell‐substratum adhesion, and its RGCt domain is required for recruitment to ventral foci.
Vedrana Filić +3 more
wiley +1 more source
, 2011 We report the direct observation of slow fluctuations of helical antiferromagnetic domains in an ultra-thin holmium film using coherent resonant magnetic x-ray scattering.
B. J. Berne +7 more
core +1 more source
Interplay between RNA‐protein interactions and RNA structures in gene regulation
FEBS Open Bio, EarlyView.Methodological advances in mapping transcriptome‐wide RNA‐protein interactions and RNA structures have started to uncover the potential of RNP conformations in gene regulation. Competing RNA–RNA, RNA‐protein and protein–protein interactions shape the compaction and function of RNPs throughout their lifetime and may provide novel therapeutic targets in ...
Jenni Rapakko +2 more
wiley +1 more source
Investigation of the speckle pattern effect for displacement assessments by DIC [PDF]
Journal of Intelligent Manufacturing and Special EquipmentPurpose – This study aims to investigate the effect of speckle pattern on displacement measurements using different speckle diameters and coverage ratios.
Salim Caliskan, Hakan Akyuz
doaj +1 more source
FEBS Open Bio, EarlyView.Skin biopsies taken from a patient with an ultra‐rare disorder as well as controls were cultured for up to 473 days. The chunks of skin were serially transferred to a new culture plate when confluent with fibroblasts. Different generations of fibroblasts were analyzed for cell and molecular properties, proliferation, and competence for reprogramming to
Sudiksha Rathan‐Kumar +3 more
wiley +1 more source